Determinants of polychlorinated biphenyl levels in plasma from 42-month-old children
Determinants of polychlorinated biphenyl levels in plasma from 42-month-old children
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DOI：
10.1007/s002449900360
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发表时间：
1998-07-01
影响因子：
4
通讯作者：
Boersma, ER
中科院分区：
文献类型：
--
作者：
Lanting, CI;Fidler, V;Boersma, ER
我们报告42个月大的儿童血浆中的PCB水平和决定这些水平的因素。我们测量了多氯联苯同系物的水平118（2，4，5 - 3 '4'五氯联苯（CB）），138（2，3，4 -2'4'5'hexaCB），153（2，4，5 - 2 '4' 5 'hexaCB）和180（2，3，4，5 - 2 '4' 5 'heptaCB）的脐带血浆、母乳和来自生活在荷兰格罗宁根地区的42个月大的儿童（n = 126）的血浆中。计算了脐带血（Sigma PCBcord）、母乳（Sigma PCBmilk）和42个月血浆（Sigma PCB 42 mo）中这四种同系物水平的总和。使用Sigma PCBcord作为产前接触的衡量标准。根据Sigma多氯联苯牛奶和哺乳期的持续时间评估了产后接触情况。此外，还记录了母亲因素，包括年龄、体重和身高、产次和正规教育。在42个月大的婴儿中，如果婴儿时期至少有六周的时间是完全母乳喂养的，则Sigma PCB 42 mo的中位数是配方奶粉喂养儿童的4.5倍（0.81 μ g/L vs. 0.18 μ g/L）。脐带血和母乳中的多氯联苯水平以及母乳喂养的持续时间可以预测42个月时的血浆多氯联苯水平。据估计，每增加一周的全母乳喂养将导致牛奶PCB水平增加0.3%。我们的结论是，哺乳是一个主要来源的儿童的PCB的身体负担在42个月。
We report on the PCB levels in plasma from 42-month-old children and the factors that determine these levels. We measured the levels of the PCB congeners 118 (2,4,5-3'4' pentachlorobiphenyl (CB)), 138 (2,3,4-2'4'5'hexaCB), 153 (2,4,5-2'4'5'hexaCB), and 180 (2,3,4,5-2'4'5'heptaCB) in cord plasma, breast milk, and plasma from 42-month-old children (n = 126) living in the Groningen area, The Netherlands. The sum of the levels of these four congeners was calculated for cord plasma (Sigma PCBcord), breast milk (Sigma PCBmilk), and 42-month plasma (Sigma PCB42mo). Sigma PCBcord was used as a measure of prenatal exposure. Postnatal exposure was assessed in terms of the Sigma PCBmilk and the duration of lactation. In addition, maternal factors including age, body weight and height, parity, and formal education were recorded. In 42-month-old children who have been fully breast-fed for at least six weeks as babies, the median Sigma PCB42mo was 4.5 times as high as that in formula-fed children (0.81 mu g/L vs. 0.18 mu g/L). The PCB levels in cord blood and human milk and the duration of breast-feeding predict the plasma PCB level at 42 months. Each additional week of full breast-feeding is estimated to result in an increase of 0.3% of the milk PCB level. We concluded that lactation is a major source for the child's PCB body burden at 42 months.