Smart Sensing Based on DNA-Metal Interaction Enables a Label-Free and Resettable Security Model of Electrochemical Molecular Keypad Lock
Smart Sensing Based on DNA-Metal Interaction Enables a Label-Free and Resettable Security Model of Electrochemical Molecular Keypad Lock
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基于DNA-金属相互作用的智能传感实现了电化学分子键盘锁的无标签且可重置的安全模型
DOI：
10.1021/acssensors.7b00735
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发表时间：
2018-01-01
期刊：
影响因子：
8.9
通讯作者：
Duan, Hongwei
中科院分区：
文献类型：
--
作者：
Du, Yan;Han, Xu;Duan, Hongwei
最近，分子键盘锁受到越来越多的关注。作为智能生物传感器的一个新的子组，它们显示出作为分子安全数据处理器保护信息的巨大潜力，而不仅仅是分子识别和定量。在此，无标记的电化学转导的Ag+和半胱氨酸（Cys）传感器的开发。基于金属离子与核酸及配体的平衡相互作用，成功实现了具有重置功能的分子键盘锁模型。正确输入“1-2-3”（即，“Ag+-Cys-cDNA”）是这种分子键盘锁的唯一密码。此外，通过半胱氨酸、缓冲液和去离子水处理，可以容易地进行正确或错误输入顺序的重置过程。因此，我们的系统提供了一个更智能的分子键盘锁系统，它可以阻止未经授权的用户的非法访问，在分子水平上的信息保护具有很大的希望。
Recently, molecular keypad locks have received increasing attention. As a new subgroup of smart biosensors, they show great potential for protecting information as a molecular security data processor, rather than merely molecular recognition and quantitation. Herein, label-free electrochemically transduced Ag+ and cysteine (Cys) sensors were developed. A molecular keypad lock model with reset function was successfully realized based on the balanced interaction of metal ion with its nucleic acid and chemical ligands. The correct input of "1-2-3" (i.e., "Ag+-Cys-cDNA") is the only password of such molecular keypad lock. Moreover, the resetting process of either correct or wrong input order could be easily made by Cys, buffer, and DI water treatment. Therefore, our system provides an even smarter system of molecular keypad lock, which could inhibit illegal access of unauthorized users, holding great promise in information protection at the molecular level.