Taste quality and hunger interactions in a feeding sensorimotor circuit.
Taste quality and hunger interactions in a feeding sensorimotor circuit.
复制标题
进食感觉运动回路中味觉品质与饥饿感的相互作用。
DOI：
10.7554/elife.79887
复制
发表时间：
2022-07-06
期刊：
影响因子：
7.7
通讯作者：
Scott, Kristin
中科院分区：
文献类型：
--
作者：
Shiu, Philip K.;Sterne, Gabriella R.;Engert, Stefanie;Dickson, Barry J.;Scott, Kristin
味觉检测和饥饿状态动态调节开始进食的决定。为了研究如何上下文适当的喂养决策的产生，我们结合了突触分辨率电路重建与有针对性的遗传访问特定的神经元，以阐明一个味觉感觉运动电路的成年果蝇喂养启动。该回路通过三个中间层将味觉感觉神经元连接到长鼻运动神经元。这条通路中的大多数神经元是必要的和足够的长鼻延伸，进食启动行为，并选择性地响应糖味检测。饥饿信号作用于选择的二级神经元，以促进食物剥夺动物的进食启动，从而放大了通路活动。与此相反，进食起始回路被苦味通路抑制，苦味通路冲击运动前神经元，照亮了一个局部的主题，权衡糖和苦味检测，以调整行为结果。总之，这些研究揭示了整合外部味觉检测和内部营养状态以灵活执行关键喂养决策的核心机制。
Taste detection and hunger state dynamically regulate the decision to initiate feeding. To study how context-appropriate feeding decisions are generated, we combined synaptic resolution circuit reconstruction with targeted genetic access to specific neurons to elucidate a gustatory sensorimotor circuit for feeding initiation in adult Drosophila melanogaster. This circuit connects gustatory sensory neurons to proboscis motor neurons through three intermediate layers. Most neurons in this pathway are necessary and sufficient for proboscis extension, a feeding initiation behavior, and respond selectively to sugar taste detection. Pathway activity is amplified by hunger signals that act at select second-order neurons to promote feeding initiation in food-deprived animals. In contrast, the feeding initiation circuit is inhibited by a bitter taste pathway that impinges on premotor neurons, illuminating a local motif that weighs sugar and bitter taste detection to adjust the behavioral outcomes. Together, these studies reveal central mechanisms for the integration of external taste detection and internal nutritive state to flexibly execute a critical feeding decision.