Homeoproteins and homeoprotein-derived peptides: going in and out.
Homeoproteins and homeoprotein-derived peptides: going in and out.
复制标题
同源蛋白和同源蛋白衍生肽：进出。
DOI：
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发表时间：
2013
影响因子：
3.1
通讯作者：
A. Joliot
中科院分区：
文献类型：
--
作者：
S. Sagan;F. Burlina;I. Alves;Cherine Bechara;E. Dupont;A. Joliot
由于最初的证据表明触角足同源异型盒可以穿过细胞膜并内化到细胞中，已经描述了许多具有类似易位性质的肽。这些肽被称为细胞穿透肽（CPP）或蛋白转导结构域（PTD）。最近发表了对已报道的CPP序列的评论，以及对其内化机制的评论。在这篇综述中，我们将专注于天然同源异型蛋白和同源异型蛋白衍生肽和描述的结果，已获得不同的实验室之间解开这些分子到达细胞的细胞质和细胞核或从一个细胞转移到另一个不同的途径。以同源异型蛋白为范例，我们也将总结内源性蛋白质易位的生理功能的最新证据。
Since the initial evidence that antennapedia homeobox can cross cell membranes and internalize into cells, numerous peptides with similar translocation properties have been described. These peptides are referred to as cell-penetrating peptides (CPPs) or protein-transduction domains (PTDs). Reviews on reported CPP sequences have been recently published, together with reviews on their mechanisms of internalization. In this review, we will focus on natural homeoproteins and homeoprotein-derived peptides and describe results that have been obtained among different laboratories to unravel the different pathways by which these molecules reach the cell cytosol and nucleus or transfer from one cell to another. Using homeoproteins as a paradigm, we will also summarize recent evidences of the physiological functions of endogenous protein translocation.
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影响因子：
4.6
作者：
Cai, SR;Xu, G;McLeod, HL
通讯作者：
McLeod, HL
DOI：
10.1073/pnas.82.10.3197
发表时间：
1985-01-01
影响因子：
11.1
作者：
ESKO, JD;STEWART, TE;TAYLOR, WH
通讯作者：
TAYLOR, WH
DOI：
10.1073/pnas.250473497
发表时间：
2000-12-05
影响因子：
11.1
作者：
Mayor, U;Johnson, CM;Fersht, AR
通讯作者：
Fersht, AR
影响因子：
7.7
作者：
Noguchi, H;Kaneto, H;Bonner-Weir, S
通讯作者：
Bonner-Weir, S