Safety considerations of polyunsaturated fatty acids
Safety considerations of polyunsaturated fatty acids
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DOI：
10.1093/ajcn/71.1.197s
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发表时间：
2000-01-01
影响因子：
7.1
通讯作者：
Eritsland, J
中科院分区：
文献类型：
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作者：
Eritsland, J
n-6和n-3多不饱和脂肪酸（PUFA）是必需的营养素;摄入相对少量的这些脂肪酸可以防止营养缺乏。用PUFAs取代膳食饱和脂肪可能会带来健康益处。实验数据支持的概念，高摄入的n-6多不饱和脂肪酸可能会增加体内脂质过氧化作用。这种影响可能会抵消膳食抗氧化剂补充剂。高n-3多不饱和脂肪酸摄入量的脂质过氧化的措施的影响一直是模棱两可的。在临床试验中，食用富含n-6或n-3 PUFA饮食的受试者的动脉粥样硬化血栓形成终点比对照组少。在这份报告中，数据的影响，多不饱和脂肪酸对脂质过氧化以及胆固醇和葡萄糖代谢，止血，和其他方面的利益进行了审查和讨论。目前，不推荐PUFA每日摄入量>总能量的10%。低于这一上限，几乎没有证据表明n-6或n-3 PUFA的高膳食摄入量意味着健康风险。
The n-6 and n-3 polyunsaturated fatty acids (PUFAs) are essential nutrients; intake of relatively small amounts of these fatty acids prevents nutritional deficiencies. Replacing dietary saturated fat with PUFAs may confer health gains. Experimental data support the notion that high intake of n-6 PUFAs may increase in vivo lipid peroxidation. This effect may be counteracted by dietary antioxidant supplementation. The influence of a high n-3 PUFA intake on measures of lipid peroxidation has been equivocal. In clinical trials, subjects who consumed diets rich in n-6 or n-3 PUFAs had fewer atherothrombotic endpoints than did control groups. In this report, data regarding the-influence of PUFAs on lipid peroxidation as well as on cholesterol and glucose metabolism, hemostasis, and other aspects of interest are reviewed and discussed. Currently, daily intake of PUFAs as >10% of total energy is not recommended. Below this ceiling there is little evidence that high dietary intake of n-6 or n-3 PUFAs implies health risks.