Chromatic Pupillometry in Children
Chromatic Pupillometry in Children
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DOI：
10.3389/fneur.2018.00669
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发表时间：
2018-08-17
影响因子：
3.4
通讯作者：
Kawasaki, Aki
中科院分区：
文献类型：
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作者：
Crippa, Sylvain, V;Domellof, Fatima Pedrosa;Kawasaki, Aki
彩色瞳孔测量是一种越来越多地用于评估视网膜疾病的技术。由于年龄可能是影响瞳孔光反应的各种因素之一，本研究旨在评估儿童人群对彩色光刺激的瞳孔反应。53名儿童视力正常，没有任何历史的眼部疾病进行了测试与便携式瞳孔计。使用了四个测试序列：暗适应3分钟后，5个暗蓝色（470 nm）刺激以半对数步长呈现，范围为-3.15至-1.15 logcd/m（2），光适应1分钟后，5个红色（622 nm）刺激为-1.15，-0.7，-0.15，0.3，和0.85 logcd/m（2），一个2.2logCD/m2的亮蓝色刺激和一个2logCD/m2的亮红色刺激。结果按年龄分组：年轻组包括27名3至10岁的儿童，老年组包括26名10岁和1个月至18岁的儿童。与老年组相比，年轻组暗适应后瞳孔直径较小。定义明视阈值的线性回归显示，年轻受试者具有较高的阈值，例如，需要更亮的红色刺激来唤起与受试者相当的阈值瞳孔反应。因此，年龄似乎影响外部视网膜敏感性，至少是通过瞳孔明视阈值强度来评价的。照明后瞳孔反应被用作内在黑视素活性的标志，并且在两个年龄组之间没有显示出任何差异。
Chromatic pupillometry is a technique that is increasingly used to assess retinal disorders. As age may be one of the various factors which can influence the pupillary light reaction, this study aimed to evaluate the pupil responses to colored light stimuli in the pediatric population. Fifty-three children with normal vision and without any history of ocular disorders were tested with a portable pupillometer. Four test sequences were used: five dim blue (470 nm) stimuli presented in half log steps ranging from -3.15 to -1.15 log cd/m(2) after 3 min of dark adaptation, five red (622 nm) stimuli of -1.15, -0.7, -0.15, 0.3, and 0.85 log cd/m(2) after 1 min light adaptation, one bright blue stimulus of 2.2 log cd/m(2) and one bright red of 2 log cd/m(2). The results were grouped by age: a younger group included 27 children aged from 3 to 10 years old and an older group included 26 from 10 and 1 month to 18 years old. The younger group had a smaller pupil diameter after dark adaptation compared with the older group. A linear regression defining the photopic threshold showed that younger subjects had a higher threshold, e.g., needed a brighter red stimulus to evoke a threshold pupil response comparable that of subjects. Age thus seems to influence outer retinal sensitivity at least as evaluated by the pupillary photopic threshold intensity. The post-illumination pupillary reaction was used as a marker of intrinsic melanopsin activity and did not show any difference between the two age groups.