Synthetic plant virology for nanobiotechnology and nanomedicine.
Synthetic plant virology for nanobiotechnology and nanomedicine.
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DOI：
10.1002/wnan.1447
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Lomonossoff GP
中科院分区：
文献类型：
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作者：
Steele JFC;Peyret H;Saunders K;Castells-Graells R;Marsian J;Meshcheriakova Y;Lomonossoff GP
纳米技术是一个迅速扩大的领域，寻求利用纳米尺度的结构，用于广泛的应用。生物衍生的纳米结构，如病毒和病毒样颗粒（VLP），由于其物理和化学性质，为功能化提供了极好的平台。植物病毒及其衍生的VLP已广泛用于生物技术。它们已经被详细表征了几十年，并具有理想的性质，包括高产率，稳健性和易于纯化。通过对病毒表面的修饰，无论是内部还是外部，植物病毒衍生的纳米颗粒已被证明支持医学和纳米技术的一系列潜在功能。在这篇综述中，我们强调了最近的和有影响力的成就，在使用植物病毒颗粒作为车辆的不同功能：从抗癌化合物的交付，有针对性的生物成像，疫苗生产纳米线的形成。WIREs Nanomed Nanobiotechnol 2017，9：e1447. doi：10.1002/wnan.1447有关本文的更多资源，请访问WIREs网站。
Nanotechnology is a rapidly expanding field seeking to utilize nano‐scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus‐like particles (VLPs), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification. Through modifications to viral surfaces, either interior or exterior, plant‐virus‐derived nanoparticles have been shown to support a range of functions of potential interest to medicine and nano‐technology. In this review we highlight recent and influential achievements in the use of plant virus particles as vehicles for diverse functions: from delivery of anticancer compounds, to targeted bioimaging, vaccine production to nanowire formation. WIREs Nanomed Nanobiotechnol 2017, 9:e1447. doi: 10.1002/wnan.1447 For further resources related to this article, please visit the WIREs website.