Hemorheological mechanisms in Alzheimer's disease
Hemorheological mechanisms in Alzheimer's disease
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DOI：
10.1080/10739680701411056
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发表时间：
2007-08-01
期刊：
影响因子：
2.4
通讯作者：
Liu, Der-Zen
中科院分区：
文献类型：
--
作者：
Chang, Chia-Yu;Liang, Hong-Jen;Liu, Der-Zen
目的：本研究的目的是阐明老年阿尔茨海默病（AD）患者血液流变学异常的潜在机制。研究对象和方法：21例AD患者和23例年龄匹配的健康对照（CON）进行了研究。我们使用一个可控剪切速率流变仪在体外产生各种流场，以模拟体内血液流动。应用实验技术对血液流变学参数进行了定量分析，包括血液粘度、红细胞变形性、红细胞聚集性和血液氧转运效率。结果表明，AD患者与CON患者的大部分血液生化指标无统计学差异，除纤维蛋白原浓度和红细胞平均体积水平（MCV）在AD患者中显著升高外。血液流变学参数，包括血液粘度，血液粘弹性在AD患者的显着高于各自的因素在CON。由于MDA水平的AD患者显着高于CON的，AD患者也表现出降低红细胞变形能力和增加血流阻力，尽管缺乏任何显着差异红细胞刚性。此外，AD患者的红细胞的侵略性高于CON和降低氧转运效率观察在AD patient.Conclusions：在AD患者中发现的血液流变学异常可能是由平行的结果，红细胞膜上的氧化损伤，可导致红细胞变形能力的降低。此外，氧化应激诱导的纤维蛋白原浓度升高可导致血流粘弹性升高导致红细胞攻击加速。综合考虑，这些因素可能会损害AD患者血液的氧转运效率。
Objective: The aim of this present study was to elucidate the underlying mechanisms responsible for hamorheological abnormalities in elderly patients with Alzheimer's disease (AD).Subjects and Methods: Twenty-one patients with AD and twenty-three age-matched healthy controls (CON) were studied. We used a controlled-shear rate rheometer generating various flow-fields in vitro for simulating blood flow in vivo. The applied experimental techniques provided valid and quantative data for the analysis of haemorheological parameters, including blood viscosity, erythrocyte deformability, erythrocyte aggregation and oxygen transport efficiency of blood were assessed.Results: The results show no statistically significant difference in most of the blood biochemical parameters between the AD patients and the CON, except that fibrinogen concentration and mean corpuscular cell volume level erythrocytes (MCV) were significantly higher in the AD patients. Hemorheological parameters including blood viscosity, and blood viscoelasticity in the AD patients were considerably higher than the respective factors in the CON. Owing to the MDA levels of the AD patients being significantly higher than that of the CON, the AD patients also showed a decrease in erythrocyte deformability and an increase in blood flow resistance despite the lack of any significant difference in erythrocyte rigidity. In addition, the erythrocyte aggression of AD patients was higher than that of the CON and reduced oxygen transport efficiency was observed in the AD patients.Conclusions: The hamorheological abnormalities found in the AD patients may be explained by the parallel findings of oxidative damage on erythrocyte membranes that could result in a decrease of erythrocyte deformability. Furthermore, the oxidative stress-induced elevation of fibrinogen concentration could lead to accelerated erythrocyte aggression as a consequence of a rise in blood flow viscoelasticity. Taken together, these factors may impair the oxygen transport efficiency of blood in AD patients.