Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.
Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.
复制标题
在运动规划过程中，额叶皮层的渐变动态会在多个时间尺度上展开。
DOI：
10.1101/2024.02.05.578819
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Howard,MW
中科院分区：
文献类型：
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作者：
Affan,RO;Bright,IM;Pemberton,LN;Cruzado,NA;Scott,BB;Howard,MW
在执行计划之前的整个过程中制定和完善计划，确保在适当的时间制定适当的行为。虽然现有的证据表明，记忆回路通过不同的神经元反应传达时间的流逝，但仍不清楚参与规划的神经回路是否表现出类似的时间动态。利用公开的数据，我们分析了在运动规划过程中，小鼠额叶运动皮层的活动是如何演变的。个别神经元表现出不同的斜坡活动，在整个延迟间隔之前的计划运动。这些神经元的集体活动有助于做出时间预测，随着运动时间的临近，时间预测变得越来越精确。这种时间上的多样性产生了一系列的编码模式，从稳定到动态的表示即将到来的运动。我们的研究结果表明，在运动规划过程中，斜坡活动在多个时间尺度上展开，这表明大脑中有一种共同的机制来处理与过去记忆和未来计划相关的时间信息。新&值得注意的是，皮层中的神经元反应是多种多样的，但这种多样性的性质和功能后果仍然不明确。我们在小鼠额叶运动皮层中发现了一种特定的时间异质性模式，即在执行运动之前，不同神经元的放电以不同的速度增加。我们的解码分析表明，这种异质性的斜坡动力学，使精确和可靠的编码的运动计划和时间在不同的时间尺度。
Plans are formulated and refined throughout the period leading up to their execution, ensuring that the appropriate behaviors are enacted at the appropriate times. Although existing evidence suggests that memory circuits convey the passage of time through diverse neuronal responses, it remains unclear whether the neural circuits involved in planning exhibit analogous temporal dynamics. Using publicly available data, we analyzed how activity in the mouse frontal motor cortex evolves during motor planning. Individual neurons exhibited diverse ramping activity throughout a delay interval that preceded a planned movement. The collective activity of these neurons was useful for making temporal predictions that became increasingly precise as the movement time approached. This temporal diversity gave rise to a spectrum of encoding patterns, ranging from stable to dynamic representations of the upcoming movement. Our results indicate that ramping activity unfolds over multiple timescales during motor planning, suggesting a shared mechanism in the brain for processing temporal information related to both memories from the past and plans for the future.NEW & NOTEWORTHYNeuronal responses in the cortex are diverse, but the nature and functional consequences of this diversity remain ambiguous. We identified a specific pattern of temporal heterogeneity in the mouse frontal motor cortex, whereby the firing of different neurons ramps up at varying speeds before the execution of a movement. Our decoding analyses reveal that this heterogeneity in ramping dynamics enables precise and reliable encoding of movement plans and time across various timescales.