Use of deuterium-labeled trimethylsilyl derivatives in mass spectrometry
Use of deuterium-labeled trimethylsilyl derivatives in mass spectrometry
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氘标记的三甲基甲硅烷基衍生物在质谱分析中的应用
DOI：
10.1021/ac60257a071
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发表时间：
1968
影响因子：
7.4
通讯作者：
A. Lawson
中科院分区：
文献类型：
--
作者：
J. McCloskey;R. N. Stillwell;A. Lawson
三甲基硅基（TMS）衍生物在质谱分析中的应用是在十年前由Sharkey， Friedel和Langer首次引入的(7)，主要用于醇类混合物的分析(2)。从那时起，TMS衍生物由于易于制备、热稳定性和挥发性，在气相液相色谱中得到了广泛的应用，例如3-6。近年来，人们对这些化合物（如1,2,7 -16）的质谱重新产生兴趣，主要有两个原因。首先，气相色谱-质谱联用的出现为气相色谱研究提供了一个合乎逻辑的扩展，包括许多天然产物的TMS衍生物的质谱分析。在甾醇和胆汁酸衍生物的情况下，这是最成功的（75）。其次，TMS衍生物挥发性的增强为质谱分析提供了一种强大的手段，可以将高分子量的多功能化合物（例如7,14）纳入其中。
The use of trimethylsilyl (TMS) derivatives in mass spectrometry was first introduced a decade ago by Sharkey, Friedel, and Langer (7), primarily for the analysis of mixtures of alcohols (2). Since that time TMS derivatives have found wide application in gas-liquid chromatography—eg, 3-6, be-cause of their ease of preparation, thermal stability, and volatility. In recent years, renewed interest in the mass spectra of these compounds—eg, 1, 2, 7-16 has come about primarily for two reasons. First, the advent of combination gas chromatography-mass spectrometry has provided a logical extension of gas chromatographic studies to include the mass spectrometry of many TMS derivatives of natural products. This has been accomplished most successfully in the case of sterol and bile acid derivatives (75). Second, the enhanced volatility of TMS derivatives has provided a powerful means of extending the scope of mass spectrometry to include polyfunctional compounds of very high molecular weight—eg, 7, 14.