Preferential enrichment: an essential crystal structure.
Preferential enrichment: an essential crystal structure.
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优先富集：重要的晶体结构。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
T. Ushio
中科院分区：
文献类型：
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作者：
H. Takahashi;R. Tamur;Z. Lepp;K. Kobayashi;T. Ushio
（+/-）-[2-[4-（2-甲基吡啶基）氨基]-2-甲基吡啶基]-2-酮的晶体结构（2-羟基己氧基）苯基氨基甲酰基]乙基]二甲基锍对氯苯磺酸盐[（+/-）-SCC]，由于原型（+/-）-[2-[4-（2-羟基己氧基）苯基氨基甲酰基]乙基]二甲基锍对氯苯磺酸盐[（+/-）-SCC]的化学修饰，（3-乙氧基-2-羟基丙氧基）苯基氨基甲酰基]乙基]二甲基锍对氯苯磺酸盐[（+/-）-SC]显示优先富集，已通过X射线晶体学分析确定。（+/-）-SCC的结晶形式不是两种对映体的混合晶体，而是外消旋化合物。此外，还对（+/-）-[2-[4-（3-乙氧基-2-羟基丙氧基）苯基氨基甲酰基]乙基]二甲基锍对甲苯磺酸盐[（+/-）-ST]和（+/-）-SC的晶体结构进行了修正，这两种化合物均表现出优先富集的性质。（+/-）-SCC的晶体结构与（+/-）-SC不同，但与（+/-）-ST非常相似。（+/-）-SC型晶相的形成，必要时可发生多晶型转变，形成（+/-）-ST型晶相，是成功富集的关键。
The crystal structure of (+/-)-[2-[4-(2-hydroxyhexyloxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-chlorobenzenesulfonate [(+/-)-SCC], which failed to effect preferential enrichment due to the chemical modification of the prototype (+/-)-[2-[4-(3-ethoxy-2- hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-chlorobenzenesulfonate [(+/-)-SC] showing preferential enrichment, has been determined by x-ray crystallographic analysis. The crystalline form of (+/-)-SCC is not a mixed crystal of the two enantiomers, but a racemic compound. In addition, the revised crystal structures of (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl] dimethylsulfonium p-toluenesulfonate [(+/-)-ST] and (+/-)-SC, both of which showed preferential enrichment, are described. The crystal structure of (+/-)-SCC is different from that of (+/-)-SC, but very similar to that of (+/-)-ST. The formation of the crystal phase of the (+/-)-SC type, which can be followed by polymorphic transition to afford the crystal one of (+/-)-ST type if necessary, seems to be essential for successful preferential enrichment.