Tissue equivalency of phantom materials for neutron dosimetry in proton therapy
Tissue equivalency of phantom materials for neutron dosimetry in proton therapy
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DOI：
10.1118/1.3250857
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发表时间：
2009-12-01
期刊：
影响因子：
3.8
通讯作者：
Rosenfeld, Anatoly
中科院分区：
文献类型：
--
作者：
Dowdell, Stephen;Clasie, Ben;Rosenfeld, Anatoly
目的：以前的蒙特卡罗和实验研究涉及质子治疗中的次级中子，采用了一些幻影材料，旨在代表人体组织。在这项研究中，作者确定了适用性的常见的幻影材料的二次中子的剂量测定，特别是儿科和颅内质子治疗treatment.Methods：这是通过比较的吸收剂量和剂量当量的幻影材料和各种ICRP组织内产生的中子。选择用于比较的体模材料为Lucite、液态水、固态水和A150组织等效塑料。这些幻影材料进行了比较，大脑，肌肉，和脂肪tissues.Results：观察到的剂量的幅度小于在以前的实验和蒙特卡罗研究，其中包括中子产生的治疗头中的报告。结果表明，对于中子吸收剂量和剂量当量，没有一种体模材料在所有考虑的点上与组织的一致性在5%以内。固体水给出了最小的平均变化与组织出场中子是主要贡献者的总dose.Conclusions：考虑的幻影材料，固体水显示出最好的协议与组织出场。(C)2009年美国医学物理学家协会。[DOI电话：10.1118/1.3250857]
Purpose: Previous Monte Carlo and experimental studies involving secondary neutrons in proton therapy have employed a number of phantom materials that are designed to represent human tissue. In this study, the authors determined the suitability of common phantom materials for dosimetry of secondary neutrons, specifically for pediatric and intracranial proton therapy treatments.Methods: This was achieved through comparison of the absorbed dose and dose equivalent from neutrons generated within the phantom materials and various ICRP tissues. The phantom materials chosen for comparison were Lucite, liquid water, solid water, and A150 tissue equivalent plastic. These phantom materials were compared to brain, muscle, and adipose tissues.Results: The magnitude of the doses observed were smaller than those reported in previous experimental and Monte Carlo studies, which incorporated neutrons generated in the treatment head. The results show that for both neutron absorbed dose and dose equivalent, no single phantom material gives agreement with tissue within 5% at all the points considered. Solid water gave the smallest mean variation with the tissues out of field where neutrons are the primary contributor to the total dose.Conclusions: Of the phantom materials considered, solid water shows best agreement with tissues out of field. (C) 2009 American Association of Physicists in Medicine. [DOI: 10.1118/1.3250857]