Symptoms of depression, acute myocardial infarction, and total mortality in a community sample
Symptoms of depression, acute myocardial infarction, and total mortality in a community sample
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DOI：
10.1161/01.cir.93.11.1976
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发表时间：
1996-06-01
期刊：
影响因子：
37.8
通讯作者：
Schroll, M
中科院分区：
文献类型：
--
作者：
Barefoot, JC;Schroll, M
背景抑郁症已被证明对已确诊的冠心病患者的预后有不利影响，但有相对较少的证据来证明抑郁症在冠心病最初发展中的作用。方法和结果研究参与者为409名男性和321名女性，他们是丹麦Glostrup的居民，出生于1914年。1964年和1974年的身体和心理检查确定了他们的基线风险因素和疾病状态以及他们的抑郁性精神障碍水平。在122名参与者中观察到初始心肌梗死（MI），在1991年结束的随访期间有290人死亡。抑郁评分的2-SD差异与MI的相对危险度1.71（P=.005）和MI的相对危险度1.59（P
Background Depression has been shown to adversely affect the prognosis of patients with established coronary artery disease, but there is comparatively little evidence to document the role of depression in the initial development of coronary disease.Methods and Results Study participants were 409 men and 321 women who were residents of Glostrup, Denmark, born in 1914. Physical and psychological examinations in 1964 and 1974 established their baseline risk factor and disease status and their level of depressive symptomatology. Initial myocardial infarction (MI) was observed in 122 participants, and there were 290 deaths during follow-up, which ended in 1991. A 2-SD difference in depression score was associated with relative risks of 1.71 (P=.005) for MI and 1.59 (P