Prothrombin fragments F1+2, thrombin-antithrombin III complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis
Prothrombin fragments F1+2, thrombin-antithrombin III complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis
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DOI：
10.1016/s0167-5273(98)00256-3
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发表时间：
1999-03-15
影响因子：
3.5
通讯作者：
Stierle, U
中科院分区：
文献类型：
--
作者：
Giannitsis, E;Siemens, HJ;Stierle, U
我们测定了57例经血管造影证实无合并外周动脉粥样硬化、脑血管疾病或糖尿病的分级冠状动脉疾病（CAD）患者和21例表面健康对照者血浆中凝血酶原片段F1+2、凝血酶-抗凝血酶III复合物（TAT）、纤维蛋白单体（FM）、d -二聚体（DD）和纤维蛋白原的水平。血管造影前通过无创伤静脉穿刺从肘前静脉采血。血浆止血标志物水平与冠心病的存在和严重程度分级有关。凝血酶原片段F1+2水平（1.74+/-0.11 vs. 1.0+/-0.07 nmol/l）
We determined the plasma levels of prothrombin fragment F1+2, thrombin-antithrombin III complexes (TAT), fibrin monomers (FM), D-dimers (DD) and fibrinogen in 57 patients with angiographically verified graded coronary artery disease (CAD) free of concomitant peripheral atherosclerosis, cerebrovascular disease or diabetes mellitus and a group of 21 apparently healthy controls.Blood was collected from the antecubital vein through atraumatic venipuncture prior to the angiographic procedure. Plasma levels of hemostatic markers were related to the presence and graded severity of CAD. The levels of prothrombin fragment F1+2 (1.74+/-0.11 vs. 1.0+/-0.07 nmol/l, P