Statistical mechanics of torque induced denaturation of DNA
Statistical mechanics of torque induced denaturation of DNA
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DOI：
10.1103/physrevlett.83.5178
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发表时间：
1999-12-13
影响因子：
8.6
通讯作者：
Monasson, R
中科院分区：
文献类型：
--
作者：
Cocco, S;Monasson, R
提出了由温度 T 驱动或由外部机械扭矩 Gamma 诱导的 DNA 变性转变的统一理论。我们的模型将氢键打开和螺旋分子结构的解旋耦合起来。我们将变性描述为从 B-DNA 阶段到 d-DNA 阶段的一级转变。共存区域自然由超螺旋程度 a 参数化。计算了变性自由能、扭转角的温度依赖性、T、Gamma 平面中的相图以及 sigma、Gamma 平面中的等温线，并与实验数据吻合良好。
A unifying theory of the denaturation transition of DNA, driven by temperature T or induced by an external mechanical torque Gamma is presented. Our model couples the hydrogen-bond opening and the untwisting of the helicoidal molecular structure. We describe denaturation as a first order transition from B-DNA to d-DNA phases. The coexistence region is naturally parametrized by the degree of supercoiling a. The denaturation free energy, the temperature dependence of the twist angle, the phase diagram in the T, Gamma plane, and isotherms in the sigma, Gamma plane are calculated and show a good agreement with experimental data.