Premature death of adult adoptees: Analyses of a case-cohort sample
Premature death of adult adoptees: Analyses of a case-cohort sample
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DOI：
10.1002/gepi.20071
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发表时间：
2005-05-01
影响因子：
2.1
通讯作者：
Sorensen, TIA
中科院分区：
文献类型：
--
作者：
Petersen, L;Andersen, PK;Sorensen, TIA
遗传和环境对成年期过早死亡风险的影响进行了调查，估计协会的总死亡率和原因特异性死亡率的成年丹麦被收养人和他们的亲生父母和养父母。在1924年至1947年期间丹麦正式批准的所有14，425例非家庭收养中，我们根据病例队列抽样设计选择了研究人群。与病例对照设计一样，病例队列设计具有收集经济数据和统计效率损失小的优点，但病例队列样本具有额外的优点，即可以获得率比估计值，并且可以在未来的其他结局研究中重复使用队列样本。使用Kalbfleisch和Lawless估计量进行风险比分析，并对方差进行稳健估计。在主要分析中，样本仅限于1924年及之后的被收养者的出生年份，以及7岁之前转移给养父母的年龄，死亡年龄限制在16至70岁。结果表明，在被收养者中，其亲生父母在16至70岁之间死亡的死亡率较高;这对自然原因、血管原因和所有原因造成的死亡都很重要。养父母的早逝没有影响，无论死因如何。(c)2005 Wiley-Liss，Inc.
Genetic and environmental influence on risk of premature death in adulthood was investigated by estimating the associations in total and cause-specific mortality of adult Danish adoptees and their biological and adoptive parents. Among all 14,425 non-familial adoptions formally granted in Denmark during the period 1924 through 1947, we selected the study population according to a case-cohort sampling design. As the case-control design, the case-cohort design has the advantage of economic data collection and little loss in statistical efficiency, but the case-cohort sample has the additional advantages that rate ratio estimates may be obtained, and re-use of the cohort sample in future studies of other outcomes is possible. Analyses were performed using Kalbfleisch and Lawless's estimator for hazard ratio, and robust estimation for variances. In the main analyses the sample was restricted to birth years of the acloptees 1924 and after, and age of transfer to the adoptive parents before 7 years, and age at death was restricted to 16 to 70 years. The results showed a higher mortality among acloptees, whose biological parents died in the age range of 16 to 70 years; this was significant for deaths from natural causes, vascular causes and all causes. No influence was seen from early death of adoptive parents, regardless of cause of death. (c) 2005 Wiley-Liss, Inc.