Motor Deficits in Schizophrenia Quantified by Nonlinear Analysis of Postural Sway
Motor Deficits in Schizophrenia Quantified by Nonlinear Analysis of Postural Sway
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DOI：
10.1371/journal.pone.0041808
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发表时间：
2012-08-01
期刊：
影响因子：
3.7
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Kent, Jerillyn S.;Hong, S. Lee;Hetrick, William P.
运动功能障碍是精神分裂症的一个持续报道但研究不足的方面。精神分裂症患者在四种不同的视觉和本体感受反馈条件下检查了姿势摇摆区：眼睛睁开或关闭，双脚并拢或肩宽分开。通过去趋势波动分析（DFA）评估姿势摇摆的非线性复杂性。精神分裂症组（n = 27）与对照组（n = 37）相比表现出更大的摇摆面积。精神分裂症患者在视觉输入被移除后，摇摆区域增加，而对照组则不存在这种模式。DFA检查显示，精神分裂症患者在去除视觉输入后，姿势摇摆的复杂性降低，复杂性发生异常变化。此外，不太复杂的姿势摇摆与精神分裂症患者症状严重程度的增加有关。考虑到小脑和相关回路在姿势稳定性和感觉运动整合中的重要参与，这些结果与越来越多的证据表明，运动，小脑和感觉整合功能障碍的障碍，以及涉及小脑缺陷和精神分裂症更普遍的功能断开的理论模型一致。
Motor dysfunction is a consistently reported but understudied aspect of schizophrenia. Postural sway area was examined in individuals with schizophrenia under four conditions with different amounts of visual and proprioceptive feedback: eyes open or closed and feet together or shoulder width apart. The nonlinear complexity of postural sway was assessed by detrended fluctuation analysis (DFA). The schizophrenia group (n = 27) exhibited greater sway area compared to controls (n = 37). Participants with schizophrenia showed increased sway area following the removal of visual input, while this pattern was absent in controls. Examination of DFA revealed decreased complexity of postural sway and abnormal changes in complexity upon removal of visual input in individuals with schizophrenia. Additionally, less complex postural sway was associated with increased symptom severity in participants with schizophrenia. Given the critical involvement of the cerebellum and related circuits in postural stability and sensorimotor integration, these results are consistent with growing evidence of motor, cerebellar, and sensory integration dysfunction in the disorder, and with theoretical models that implicate cerebellar deficits and more general disconnection of function in schizophrenia.