No genetic contribution to variation in human offspring sex ratio: a total population study of 4.7 million births
No genetic contribution to variation in human offspring sex ratio: a total population study of 4.7 million births
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人类后代性别比的变化没有遗传因素：对 470 万新生儿的总人口研究
DOI：
10.1098/rspb.2019.2849
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
R. Kuja‐Halkola
中科院分区：
文献类型：
--
作者：
Brendan P. Zietsch;H. Walum;P. Lichtenstein;K. Verweij;R. Kuja‐Halkola
一个个体的后代在出生时的男女比例（后代性别比）长期以来一直是进化生物学家的极大兴趣。人类后代的性别比例大约是1：1，主要是根据费舍尔原则（R。A.自然选择的遗传学理论，1930），这是基于这样的见解，即在一个不平等的性别比例的人口中，每个个体的稀有性别将平均有更大的生殖价值比每个个体的更常见的性别。因此，在遗传上倾向于产生稀有性别的个体往往具有更大的适应性，因此倾向于产生该性别的基因的频率将增加，直到人口性别比接近1：1。这种观点的一个假设是，个体的后代性别比是可遗传的。然而，人类的遗传性仍然非常不确定，现有研究的结果不一致和重要的权力限制。为了解决这种持续的不确定性，我们使用了1932年或以后出生的整个瑞典出生人口的数据，包括3543243人及其4753269名子女。为了研究后代性别比是否受遗传变异的影响，我们测试了个体后代性别与其兄弟姐妹后代性别之间的关联（n对= 14015421）。我们估计，后代性别比的遗传力为零，95%置信区间上限为0.002，使费舍尔的原则和其他几个现有的假设是站不住脚的理解人类后代性别比的框架。
The ratio of males to females among an individual's offspring at birth (offspring sex ratio) has long been of great interest to evolutionary biologists. The human offspring sex ratio is around 1 : 1 and is understood primarily in terms of Fisher's principle (R. A. Fisher, The genetical theory of natural selection, 1930), which is based on the insight that in a population with an unequal sex ratio, each individual of the rarer sex will on average have greater reproductive value than each individual of the more common sex. Accordingly, individuals genetically predisposed to produce the rarer sex will tend to have greater fitness and thus genes predisposing to bearing that sex will increase in frequency until the population sex ratio approaches 1 : 1. An assumption of this perspective is that individuals' offspring sex ratio is heritable. However, the heritability in humans remains remarkably uncertain, with inconsistent findings and important power limitations of existing studies. To address this persistent uncertainty, we used data from the entire Swedish-born population born 1932 or later, including 3 543 243 individuals and their 4 753 269 children. To investigate whether offspring sex ratio is influenced by genetic variation, we tested the association between individuals' offspring's sex and their siblings' offspring's sex (n pairs = 14 015 421). We estimated that the heritability for offspring sex ratio was zero, with an upper 95% confidence interval of 0.002, rendering Fisher's principle and several other existing hypotheses untenable as frameworks for understanding human offspring sex ratio.
人类性别比例变异的两代研究。
影响因子：
9.8
作者：
Curtsinger,JW;Ito,R;Hiraizumi,Y
通讯作者：
Hiraizumi,Y