An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo.
An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo.
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DOI：
10.1002/mrm.26909
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发表时间：
2018-05
影响因子：
3.3
通讯作者：
Samson RS
中科院分区：
文献类型：
--
作者：
Battiston M;Grussu F;Ianus A;Schneider T;Prados F;Fairney J;Ourselin S;Alexander DC;Cercignani M;Gandini Wheeler-Kingshott CAM;Samson RS
建立一个框架，在临床可行的时间内充分表征人体颈髓体内的定量磁化传递指数。使用具有回波平面成像（EPI）读数的缩小视野方法开发了用于定量磁化转移的专用脊髓成像方案。基于Cramer-Rao-下限优化序列参数。定量模型参数（即，结合池分数，自由和结合池横向弛豫时间[，]，和远期汇率[kFB]）估计实施能够处理所采用的序列的新颖性的数值模型。该框架在五名健康受试者身上进行了测试。Cramer-Rao-lower boundary minimization产生最佳采样方案，而无需建立稳态MT效应。所提出的框架允许在通常用于脊髓成像的分辨率（即0.75 × 0.75 × 5 mm 3）下对模型参数进行定量体素估计，方案持续时间为35 min。定量磁化传递参数图与文献值一致。全脐带平均值为：结合池分数= 0.11（±0.01）， = 46.5（±1.6）ms， = 11.0（±0.2）µs，k FB = 1.95（±0.06）Hz。方案优化对再现性具有有益的影响，特别是对于 k FB。开发的框架能够使用qMT在体内对脊髓微结构进行鲁棒表征。Magn Reson Med 79：2576-2588，2018。© 2017 The Authors Magnetic Resonance in Medicine出版由Wiley Periodicals，Inc.国际医学磁共振学会（International Society for Magnetic Resonance in Medicine）这是一个开放获取的条款下的知识共享署名许可证，允许使用，分发和复制在任何媒体上，只要原始作品是适当的引用。
To develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time. A dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field‐of‐view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the Cramer‐Rao‐lower bound. Quantitative model parameters (i.e., bound pool fraction, free and bound pool transverse relaxation times [ , ], and forward exchange rate [k FB]) were estimated implementing a numerical model capable of dealing with the novelties of the sequence adopted. The framework was tested on five healthy subjects. Cramer‐Rao‐lower bound minimization produces optimal sampling schemes without requiring the establishment of a steady‐state MT effect. The proposed framework allows quantitative voxel‐wise estimation of model parameters at the resolution typically used for spinal cord imaging (i.e. 0.75 × 0.75 × 5 mm3), with a protocol duration of ∼35 min. Quantitative magnetization transfer parametric maps agree with literature values. Whole‐cord mean values are: bound pool fraction = 0.11(±0.01), = 46.5(±1.6) ms, = 11.0(±0.2) µs, and k FB = 1.95(±0.06) Hz. Protocol optimization has a beneficial effect on reproducibility, especially for and k FB. The framework developed enables robust characterization of spinal cord microstructure in vivo using qMT. Magn Reson Med 79:2576–2588, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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