Effects of radiation on tumor vasculature
Effects of radiation on tumor vasculature
复制标题
辐射对肿瘤血管系统的影响
DOI：
10.1002/mc.23360
复制
发表时间：
2021-10-13
影响因子：
4.6
通讯作者：
Young, Kristina H.
中科院分区：
文献类型：
--
作者：
Yamazaki, Tomoko;Young, Kristina H.
放射已被用作直接的细胞毒性杀肿瘤方式，然而，放射对肿瘤血管系统的影响影响对抗癌治疗的反应。虽然许多报告已经证明了血管的变化，在辐射肿瘤，发现和影响是广泛的，有时矛盾的辐射剂量，时间，和模型使用。在这篇综述中，我们专注于辐射介导的肿瘤血管系统的影响方面的剂量，时间postradiation，血管生成，粘附分子的表达，渗透性和周细胞覆盖，包括最新的研究结果。
Radiation has been utilized as a direct cytotoxic tumorcidal modality, however, the effect of radiation on tumor vasculature influences response to anticancer therapies. Although numerous reports have demonstrated vascular changes in irradiated tumors, the findings and implications are extensive and at times contradictory depending on the radiation dose, timing, and models used. In this review, we focus on the radiation-mediated effects on tumor vasculature with respect to doses used, timing postradiation, vasculogenesis, adhesion molecule expression, permeability, and pericyte coverage, including the latest findings.