Uptake and clearance of 5-fluorouridine following subconjunctival and intravitreal injection.
Uptake and clearance of 5-fluorouridine following subconjunctival and intravitreal injection.
复制标题
结膜下和玻璃体内注射后 5-氟尿苷的摄取和清除。
DOI：
10.1097/00006982-198808030-00011
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hartzer,M
中科院分区：
文献类型：
--
作者：
Huang,DS;Blumenkranz,MS;Hernandez,E;Hartzer,M
colon; Described are some pharmacokinetic parameters for 5-fluorouridine, a potentially useful intermediate metabolite of 5-fluorouracil (5-FU), following subconjunctival and intravitreal injection in the pigmented rabbit. Immediately following a 500 [mu] g intravitreal injection of 3H-5-fluorouridine, a peak ipsilateral vitreous concentration of 308 [mu] g/ml was measured. This decreased to 199 [mu] g/ml at 2 hours, 33 [mu] g/ml at 12 hours and 4.4 [mu] g/ml at 24 hours, indicating that 5-fluorouridine is cleared from the vitreous at a rate similar to 5-fluorouracil. Aqueous concentrations in the ipsilateral eye reached a maximum at 6 hours (9.6 [mu] g/ml) and decreased to 0.8 [mu] g/ml at 24 hours. Following subconjunctival injection of 5 mg 3H-5-fluorouridine (0.5 ml), peak ipsilateral anterior chamber concentration of 10.7 [mu] g/ml was measured 1 hour after injection and decreased to 2.4 [mu] g/ml after 12 hours. Maximum vitreal concentrations of 1.7 [mu] g/ml were measured 12 hours after injection. RETINA 8: 205-209, 1988
