Liquid Bandage Harvests Robust Adhesive, Hemostatic, and Antibacterial Performances as a First-Aid Tissue Adhesive
Liquid Bandage Harvests Robust Adhesive, Hemostatic, and Antibacterial Performances as a First-Aid Tissue Adhesive
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DOI：
10.1002/adfm.202001820
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发表时间：
2020-08-12
影响因子：
19
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Ma, Yufei;Yao, Jingxuan;Xu, Feng
组织创伤后大量出血和伤口感染是灾害中伤亡人员的主要危险因素，迫切需要能够极大地实现伤口闭合、有效控制出血和感染的急救用品。虽然现有的组织粘合剂可以粘附到组织表面并实现快速伤口闭合，但它们中的大多数具有有限的止血和抗菌能力，使得它们不适合作为急救组织粘合剂。在这项研究中，受到壳聚糖固有的止血和抗菌能力以及源自席夫碱反应的优异组织整合能力的启发，液体绷带（LBA），一种原位亚胺交联的光响应性壳聚糖水凝胶（NB-CMC/CMC水凝胶），被开发用于紧急伤口管理。在紫外光照射下，改性羧甲基壳聚糖（CMC）中的邻硝基苯转化为邻硝基苯甲醛，与组织表面的氨基发生交联，赋予LBA上级组织粘附性能。LBA的止血和抗菌性能可以通过NB-CMC/CMC的质量比来调节。此外，它具有令人满意的生物相容性、生物降解性和增强伤口愈合过程的能力。这项研究为开发一种多功能水凝胶急救组织粘合剂提供了新的思路，该粘合剂可以实现强大的组织粘合，有效控制出血，防止细菌感染，促进伤口愈合。
Massive bleeding and wound infection after tissue trauma are the major dangerous factors of casualties in disasters; hence, first-aid supplies that can greatly achieve wound closure and effectively control the hemorrhage and infection are urgently needed. Although existing tissue adhesives can adhere to the tissue surfaces and achieve rapid wound closure, most of them have limited hemostatic and antibacterial capacities, making them unsuitable as the first-aid tissue adhesives. In this study, inspired by the inherent hemostatic and antibacterial capacities of chitosan and the excellent tissue integration capacity originating from a Schiff base reaction, liquid bandage (LBA), an in situ imine crosslinking-based photoresponsive chitosan hydrogel (NB-CMC/CMC hydrogel), is developed for emergency wound management. Upon UV irradiation,o-nitrobenzene in modified carboxymethyl chitosan (CMC) converts too-nitrosobenzaldehyde that subsequently crosslinks with amino groups on tissue surface, which endows the LBA with superior tissue adhesive performance. LBA's hemostatic and antibacterial properties can be tuned by the mass ratio of NB-CMC/CMC. Moreover, it exhibits satisfactory biocompatibility, biodegradability, and the capability to enhance wound healing process. This study sheds new light on the development of a multifunctional hydrogel-based first-aid tissue adhesive that can achieve robust tissue adhesion, effectively control bleeding, prevent bacterial infection, and promote wound healing.