High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
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DOI：
10.1186/s12986-015-0024-3
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发表时间：
2015
影响因子：
4.5
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Ning B;Wang X;Yu Y;Waqar AB;Yu Q;Koike T;Shiomi M;Liu E;Wang Y;Fan J
患有胰岛素抵抗并导致糖耐量受损以及 2 型糖尿病的个体动脉粥样硬化患病率增加。我们本研究的目的是探讨饮食诱导的胰岛素抵抗是否在高脂血症兔的主动脉和冠状动脉粥样硬化的发展中发挥作用。我们用限制正常热量的高果糖和高脂肪饮食（HFFD）喂养渡边遗传性高脂血症（WHHL）兔子，并将主动脉和冠状动脉粥样硬化的病变与喂养正常饮食的对照 WHHL 兔子的病变进行比较。 HFFD 喂养的 WHHL 兔子表现出胰岛素抵抗和糖耐量受损，并伴有血浆脂质水平升高和脂肪组织积累，尽管与对照兔子相比，它们的体重没有变化。 8周时，HFFD喂养的WHHL兔子的主动脉大体病变面积比对照组增加了40%，其病变特征是巨噬细胞和平滑肌细胞数量增加。 16周时，HFFD喂养的WHHL兔的病变出现更严重的病变，例如脂质核心形成和钙化。此外，喂食 HFFD 的 WHHL 兔子的冠状动脉粥样硬化显着增加。这些结果表明胰岛素抵抗加速了动脉粥样硬化病变的形成。本文的在线版本 (doi:10.1186/s12986-015-0024-3) 包含补充材料，可供授权用户使用。
Individuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Our aim in this study was to address whether diet-induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. We fed Watanabe heritable hyperlipidemic (WHHL) rabbits with a high-fructose and high-fat diet (HFFD) with restricted normal calories and compared the lesions of both aortic and coronary atherosclerosis with those of control WHHL rabbits fed a normal chow diet. HFFD-fed WHHL rabbits showed insulin resistance and impaired glucose tolerance accompanied by elevated plasma lipid levels and accumulation of adipose tissue even though their body weight was unchanged compared to the control rabbits. At 8 weeks, the aortic gross lesion area of HFFD-fed WHHL rabbits was increased by 40 % over the controls and their lesions were characterized by increased number of macrophages and smooth muscle cells. At 16 weeks, the lesions of HFFD-fed WHHL rabbits showed more advanced lesions such as lipid core formation and calcification. In addition, coronary atherosclerosis was significantly increased in HFFD-fed WHHL rabbits. These results suggest that insulin resistance accelerates lesion formation of atherosclerosis. The online version of this article (doi:10.1186/s12986-015-0024-3) contains supplementary material, which is available to authorized users.