Graves' disease as a driver of depression: a mechanistic insight.
Graves' disease as a driver of depression: a mechanistic insight.
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DOI：
10.3389/fendo.2023.1162445
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
格雷夫斯病（GD）的特点是甲状腺弥漫性肿大和过度活跃，可能伴有其他身体症状。其中，抑郁症会严重损害患者的生活质量，但其在GD中的患病率尚未得到足够的重视。一些研究已经证实 GD 与抑郁症风险增加之间存在很强的相关性，尽管目前研究的数据仍然有限。关于 GD 和抑郁症的机制见解的总结支持了 GD 导致抑郁症的可能途径。在这篇综述中，我们首先总结了支持 GD 导致抑郁症患病率增加的临床证据。然后，我们集中研究与 GD 背景下抑郁症加速相关的机制发现，因为越来越多的证据表明，GD 通过各种机制促进抑郁症的发展，包括触发自身免疫反应、诱导激素紊乱以及影响甲状腺-肠道-微生物组-大脑轴。最后，我们简要介绍了降低 GD 患者抑郁风险的潜在治疗方法。
Graves’ disease (GD) is characterized by diffuse enlargement and overactivity of the thyroid gland, which may be accompanied by other physical symptoms. Among them, depression can dramatically damage patients’ quality of life, yet its prevalence in GD has not received adequate attention. Some studies have established a strong correlation between GD and increased risk of depression, though the data from current study remains limited. The summary of mechanistic insights regarding GD and depression has underpinned possible pathways by which GD contributes to depression. In this review, we first summarized the clinical evidence that supported the increased prevalence of depression by GD. We then concentrated on the mechanistic findings related to the acceleration of depression in the context of GD, as mounting evidence has indicated that GD promotes the development of depression through various mechanisms, including triggering autoimmune responses, inducing hormonal disorders, and influencing the thyroid-gut-microbiome-brain axis. Finally, we briefly presented potential therapeutic approaches to decreasing the risk of depression among patients with GD.
影响因子：
2.1
作者：
Fukao A;Takamatsu J;Kubota S;Miyauchi A;Hanafusa T
通讯作者：
Hanafusa T