Molecular mechanisms of polymyxin resistance: knowns and unknowns
Molecular mechanisms of polymyxin resistance: knowns and unknowns
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DOI：
10.1016/j.ijantimicag.2016.06.023
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发表时间：
2016-12-01
影响因子：
10.8
通讯作者：
Olaitan, Abiola Olumuyiwa
中科院分区：
文献类型：
--
作者：
Baron, Sophie;Hadjadj, Linda;Olaitan, Abiola Olumuyiwa
粘菌素，也被称为多粘菌素E，是一种有效的抗生素，对大多数多重耐药革兰氏阴性菌，目前被用作治疗严重细菌感染的最后一线药物。在过去的几年里，粘菌素耐药性逐渐增加，对其多方面机制的了解正在扩大。这包括新发现的质粒介导的粘菌素耐药基因mcr-1，该基因在首次报告后3个月内已在20多个国家被检测到。我们之前在2014年的第一次审查中报告了多粘菌素耐药性的所有已知机制，但考虑到最近在该领域取得的重大发现，2016年似乎有必要进行更新。本次综述提供了有关粘菌素耐药性的已知信息、新信息以及一些未解决问题的最新信息。(C)2016 Elsevier B. V.和国际化疗学会。All rights reserved.
Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe bacterial infections. Colistin resistance has increased gradually for the last few years, and knowledge of its multifaceted mechanisms is expanding. This includes the newly discovered plasmid-mediated colistin resistance gene mcr-1, which has been detected in over 20 countries within 3 months of its first report. We previously reported all of the known mechanisms of polymyxin resistance in our first review in 2014, but an update seems necessary in 2016, considering the significant recent discoveries that have been made in this domain. This review provides an update about what is already known, what is new, and some unresolved questions with respect to colistin resistance. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.