Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt.
Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt.
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DOI：
10.3390/ijms24054294
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发表时间：
2023-02-21
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
代谢综合征表现为内脏肥胖、高血压、葡萄糖耐受不良、高胰岛素血症和血脂异常。根据CDC的数据，自20世纪60年代以来，美国的代谢综合征急剧增加，导致慢性疾病和医疗费用上升。高血压是代谢综合征的一个重要组成部分，与中风、心血管疾病和肾脏疾病引起的发病率和死亡率增加有关。然而，代谢综合征中高血压的发病机制仍然知之甚少。代谢综合征主要由热量摄入增加和体力活动减少引起。流行病学研究表明，果糖和蔗糖形式的糖的消费增加与代谢综合征的患病率增加相关。高脂肪含量的饮食，再加上果糖和盐的摄入量增加，会加速代谢综合征的发展。这篇综述文章讨论了代谢综合征中高血压发病机制的最新文献，特别强调了果糖的作用及其对小肠和肾小管盐吸收的刺激作用。
Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance, hyperinsulinism, and dyslipidemia. According to the CDC, metabolic syndrome in the US has increased drastically since the 1960s leading to chronic diseases and rising healthcare costs. Hypertension is a key component of metabolic syndrome and is associated with an increase in morbidity and mortality due to stroke, cardiovascular ailments, and kidney disease. The pathogenesis of hypertension in metabolic syndrome, however, remains poorly understood. Metabolic syndrome results primarily from increased caloric intake and decreased physical activity. Epidemiologic studies show that an enhanced consumption of sugars, in the form of fructose and sucrose, correlates with the amplified prevalence of metabolic syndrome. Diets with a high fat content, in conjunction with elevated fructose and salt intake, accelerate the development of metabolic syndrome. This review article discusses the latest literature in the pathogenesis of hypertension in metabolic syndrome, with a specific emphasis on the role of fructose and its stimulatory effect on salt absorption in the small intestine and kidney tubules.
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影响因子：
4.9
作者：
Chávez-Canales M;Arroyo JP;Ko B;Vázquez N;Bautista R;Castañeda-Bueno M;Bobadilla NA;Hoover RS;Gamba G
通讯作者：
Gamba G
影响因子：
4.8
作者：
Barone, Sharon;Fussell, Stacey L.;Soleimani, Manoocher
通讯作者：
Soleimani, Manoocher
影响因子：
15.9
作者：
DEFRONZO, RA;COOKE, CR;DAVIS, PJ
通讯作者：
DAVIS, PJ
影响因子：
5.6
作者：
Flisiński M;Brymora A;Skoczylas-Makowska N;Stefańska A;Manitius J
通讯作者：
Manitius J
影响因子：
29.4
作者：
Foulke-Abel J;In J;Yin J;Zachos NC;Kovbasnjuk O;Estes MK;de Jonge H;Donowitz M
通讯作者：
Donowitz M