One-Year Costs in Patients With a History of or at Risk for Atherothrombosis in the United States
One-Year Costs in Patients With a History of or at Risk for Atherothrombosis in the United States
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DOI：
10.1161/circoutcomes.108.775247
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发表时间：
2008-09-01
影响因子：
6.9
通讯作者：
Bhatt, Deepak L.
中科院分区：
文献类型：
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作者：
Mahoney, Elizabeth M.;Wang, Kaijun;Bhatt, Deepak L.
背景-动脉粥样硬化血栓形成是心血管、脑血管和外周动脉疾病的根本原因，也是工业化国家的主要死亡原因。本研究的目的是（1）检查与需要住院治疗的血管事件和干预相关的年度费用，以及用于管理相关风险因素的长期药物使用，在具有多种动脉粥样硬化血栓形成危险因素或有症状疾病史的美国门诊患者人群中，（2）比较根据特定动脉床定义的患者亚组的费用（方法和结果-国际减少动脉粥样硬化血栓形成以保持健康（REACH）登记处招募了年龄≥ 45岁的门诊患者，这些患者已经确定了冠状动脉、脑血管或外周动脉疾病或≥ 3个动脉粥样硬化血栓形成危险因素。收集了有关危险因素、相关药物、血管住院和干预的数据。在总计68236例患者的REACH队列中，25763例入组来自美国研究中心。23974例（93%）美国患者的完整1年数据可用。每年的药物费用从2401美元到3481美元不等。基线时0（n = 6145）、1（n = 14353）、2（n = 3106）和3（n = 370）个动脉床受累患者的平均年住院费用分别为1344、2864、4824和8155美元（P
Background-Atherothrombosis is the underlying cause of cardiovascular, cerebrovascular, and peripheral arterial disease and is the leading cause of death in the industrialized world. The objectives of the present study are ( 1) to examine the annual costs associated with vascular events and interventions that require hospitalization, as well as long-term medication use for the management of associated risk factors, in a US population of outpatients with multiple atherothrombotic risk factors or a history of symptomatic disease and ( 2) to compare costs across patient subgroups defined according to specific arterial bed(s) affected and the number of affected arterial beds.Methods and Results-The international REduction of Atherothrombosis for Continued Health (REACH) Registry enrolled outpatients >= 45 years of age who had established coronary artery, cerebrovascular, or peripheral artery disease or >= 3 atherothrombotic risk factors. Data on risk factors, associated medications, and vascular hospitalizations and interventions were collected. Of the total 68 236-patient REACH cohort, 25 763 were enrolled from US sites. Complete 1-year data were available for 23 974 (93%) of the US patients. Annualized medication costs ranged from $2401 to $3481. Mean annual hospitalization costs per patient were $1344, $2864, $4824, and $8155 for patients with 0 (n = 6145), 1 (n = 14 353), 2 (n = 3106), and 3 (n = 370) affected arterial beds at baseline (P