MCCOLLUM AWARD LECTURE, 1994 - VITAMIN-D - NEW HORIZONS FOR THE 21ST-CENTURY
MCCOLLUM AWARD LECTURE, 1994 - VITAMIN-D - NEW HORIZONS FOR THE 21ST-CENTURY
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DOI：
10.1093/ajcn/60.4.619
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发表时间：
1994-10-01
影响因子：
7.1
通讯作者：
HOLICK, MF
中科院分区：
文献类型：
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作者：
HOLICK, MF
维生素 D 对于维持我们一生的骨骼健康绝对至关重要。越来越多的证据表明，维生素 D 不足和老年人维生素 D 缺乏是一种无声的流行病，会导致骨质流失和骨折。大多数人只要偶尔接触阳光就可以满足维生素 D 的需求。季节变化、一天中的时间、纬度、衰老、防晒霜的使用和黑色素沉着可显着影响皮肤维生素 D 的生成。虽然成人维生素 D 的推荐膳食摄入量为 5 微克（200 IU），但越来越多的证据表明，在没有阳光照射的情况下，维生素 D 的需求量至少为 15 微克（600 IU）/天。皮肤是活性维生素 D（1,25-二羟基胆钙化醇）的目标组织。 1,25-二羟基胆钙化醇抑制培养的角质形成细胞的增殖并诱导其分化。 1,25-二羟基胆钙化醇及其类似物已被开发为治疗过度增殖性皮肤病牛皮癣的有效新疗法。
Vitamin D is absolutely essential for the maintenance of a healthy skeleton throughout our lives. There is mounting evidence that vitamin D insufficiency and vitamin D deficiency in elderly people is a silent epidemic that results in bone loss and fractures. It is casual exposure to sunlight that provides most humans with their vitamin D requirement. Seasonal changes, time of day, latitude, aging, sunscreen use, and melanin pigmentation can substantially influence the cutaneous production of vitamin D. Although the recommended dietary allowance for vitamin D in adults is 5 mu g (200 IU), there is mounting evidence that in the absence of exposure to sunlight the vitamin D requirement is at least 15 mu g (600 IU)/d. The skin is a target tissue for the active form of vitamin D (1,25-dihydroxycholecalciferol). 1,25-Dihydroxycholecalciferol inhibits the proliferation of cultured keratinocytes and induces them to differentiate. 1,25-Dihydroxycholecalciferol and its analogs have been developed as an effective new therapy for the treatment of the hyperproliferative skin disease psoriasis.