COXSACKIE VIRUS B3 MYOCARDITIS IN MICE. AN ELECTRON MICROSCOPIC, IMMUNOFLUORESCENT AND VIRUS-ASSAY STUDY.
COXSACKIE VIRUS B3 MYOCARDITIS IN MICE. AN ELECTRON MICROSCOPIC, IMMUNOFLUORESCENT AND VIRUS-ASSAY STUDY.
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小鼠柯萨奇病毒 B3 心肌炎。
DOI：
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发表时间：
1964
影响因子：
6
通讯作者：
J. Melnick
中科院分区：
文献类型：
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作者：
E. Rabin;S. Hassan;A. Jenson;J. Melnick
大量报道表明，新生儿致命心肌炎与实验性柯萨奇B病毒感染有关，这重新引起了人们对柯萨奇B病毒感染的兴趣。在柯萨奇B感染死亡的哺乳小鼠中发现了Y-5心脏病变，但这种病变不常见，范围小。Gifford和Dalldorf6观察到，在接种了几种不同类型的柯萨奇B病毒后，51只哺乳小鼠中只有3只（6%）患上了心肌炎。梅尔尼克和戈德曼7报道，腹腔注射康涅狄格-5株柯萨奇杆菌后，4至5日龄小鼠心肌炎发病率为29%。最近，Grodums和Dempster8报道，在年龄稍大的小鼠中，可能会诱发更频繁和更严重的心脏病变；2 ~ 23日龄接种的动物心脏病变最严重。这些工人使用了柯萨奇B3的南希菌株。正是出于这个原因，在本研究中选择了这种病毒株和类似年龄范围的小鼠。本研究采用电镜、免疫荧光和病毒检测等方法探讨心肌损伤的发生发展及其与病毒增殖的关系。
Renewed interest in experimental Coxsackie B viral infection has been brought about by the numerous reports implicating this group of viruses in fatal newborn myocarditis.Y-5 Cardiac lesions had been noted in suckling mice dying of Coxsackie B infections, but such lesions were infrequent and small in extent. Gifford and Dalldorf6 observed that only 3 of 5I (6 per cent) suckling mice developed myocarditis after inoculation with several different types of Coxsackie B virus. Melnick and Godman 7 reported an incidence of myocarditis of 29 per cent in 4to s-day-old mice after intraperitoneal inoculation with the Connecticut-5 strain of Coxsackie Bi. More recently, Grodums and Dempster8 reported that much more frequent and severe cardiac lesions could be induced in slightly older mice; heart lesions were most severe in animals inoculated at I2 to 23 days of age. These workers used the Nancy strain of Coxsackie B3. It was for this reason that this strain of virus and a similar age range of mice were selected in the present study. The purpose of this study was to examine the development of myocardial damage and its relationship to viral multiplication by means of electron microscopy, immunofluorescence and virus assay.