PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING IN NEONATAL STROKE
PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING IN NEONATAL STROKE
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DOI：
10.1055/s-2007-979764
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发表时间：
1995-10-01
期刊：
影响因子：
1.4
通讯作者：
DEVRIES, LS
中科院分区：
文献类型：
--
作者：
GROENENDAAL, F;VANDERGROND, J;DEVRIES, LS
To study cerebral metabolism in neonates after unilateral cerebral infarcts 4 neonates (3 full-terms, one preterm with a gestational age of 35 weeks) with unilateral cerebral infarcts were examined at 7 to 49 days of postnatal age, using proton magnetic resonance spectroscopic imaging (H-1-MRSI). Three neonates had infarcts of the left middle cerebral artery (MCA), one had a right posterior cerebral artery infarct and a more localized anterior lesion. Examinations were repeated in the three fullterm infants aged 2-3 months.Lactate resonances, which are not present in normal brain after term age, were demonstrated in two patients tested at 7 and 10 days of age respectively, and in one of them lactate was still present at two months. Ln all four neonates a decrease of the N-acetylaspartate/choline (NAA/Cho) ratio was seen within the area of infarction. Repeated MRS of two infants at three months showed an increase in NAA/Cho ratios in all brain areas, but values remained below normal in the infarcts. In the third infant a further decrease in the NAA/Cho ratio was demonstrated in the area of infarction at two months. The NAA/Cho ratios in the surrounding and contralateral brain tissue were normal in all infants. AU three infants with a MCA infarct developed a hemiplegia.The aforementioned metabolic alterations in neonates with cerebral infarcts, demonstrated using H-1-MRSI, were found to be confined to the area of infarction and abnormalities persisted beyond the neonatal period.
