No effect of short-term dietary supplementation of saturated and poly- and monounsaturated fatty acids on insulin secretion and sensitivity in healthy men
No effect of short-term dietary supplementation of saturated and poly- and monounsaturated fatty acids on insulin secretion and sensitivity in healthy men
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DOI：
10.1159/000177904
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发表时间：
1996-03-01
影响因子：
3.9
通讯作者：
Waldhausl, W
中科院分区：
文献类型：
--
作者：
Fasching, P;Ratheiser, K;Waldhausl, W
为了评估不同饱和度的脂肪酸对胰岛素分泌和敏感性的短期影响，8 名健康男性（年龄 26 +/- 3.5 岁，体重指数 22.4 +/- 1.8 kg/m(2)）每天摄入 800 kcal 碳水化合物（CH；200 g）或富含饱和脂肪酸（SAFA；72%）或（omega-6）的脂肪（90 g）除了标准饮食（2,000 kcal/天；50% CH、15% 蛋白质和 35% 脂肪；SAFA、MUFA 和 PUFA 各 33%）之外，按随机顺序添加多不饱和脂肪酸（PUFA；60%）或顺式单不饱和脂肪酸（MUFA；40%；n = 5）1 周（清除期 2 周）。通过频繁采样的静脉内葡萄糖耐量试验（FSIGT；0.3g葡萄糖/kg体重）对刺激的胰岛素分泌进行定量，而胰岛素敏感性则通过正常血糖-高胰岛素5-mU钳夹测定。同时，通过间接量热法估计基础和刺激的碳水化合物和脂肪氧化率。一周的限定脂肪暴露未能显着影响 FSIGT 期间葡萄糖诱导的胰岛素分泌和正常血糖钳夹期间胰岛素依赖性葡萄糖处理（M 值：CH 9.6 +/- 1.6 mg/kg 度/分钟、SAFA 9.7 +/- 2.2、PUFA 9.8 +/- 2.5 和 MUFA 11.5 +/- 3.2 mg/kg . 分钟；NS）。此外，不同饮食之间在吸收后状态和高胰岛素血症期间脂肪和葡萄糖的氧化率没有差异。我们得出的结论是，由于健康受试者的代偿代谢能力，短期（1周）在标准饮食中补充不同饱和度脂肪酸的等热量不会影响健康男性的胰岛素分泌或胰岛素敏感性。
To evaluate the short-term influence of fatty acids with different grades of saturation on insulin secretion and sensitivity, 8 healthy males (age 26 +/- 3.5 years, body mass index 22.4 +/- 1.8 kg/m(2)) were provided with 800 kcal daily of either carbohydrates (CH; 200 g), or fat (90 g) enriched either with saturated fatty acids (SAFA; 72%) or (omega-6) polyunsaturated fatty acids (PUFA; 60%) or cis-monounsaturated fatty acids (MUFA; 40%; n = 5) in addition to a standard diet (2,000 kcal/day; 50% CH, 15% protein, and 35% fat; 33% SAFA, MUFA, and PUFA each) for 1 week in a randomized order (washout period 2 weeks). The stimulated insulin secretion was quantified by the frequently sampled intravenous glucose tolerance test (FSIGT; 0.3 g glucose/kg body weight), while the insulin sensitivity was determined by an euglycemic-hyperinsulinemic 5-mU clamp. In parallel, basal and stimulated carbohydrate and fat oxidation rates were estimated by indirect calorimetry. One week of defined fat exposure failed to significantly affect the glucose-induced insulin secretion during FSIGT and insulin-dependent glucose disposal during an euglycemic clamp (M values: CH 9.6 +/- 1.6 mg/kg degrees min, SAFA 9.7 +/- 2.2, PUFA 9.8 +/- 2.5, and MUFA 11.5 +/- 3.2 mg/kg . min; NS). In addition, oxidation rates for fat and glucose in the postabsorptive state and during hyperinsulinemia did not differ between the different diets. We conclude that short-term (1-week) isocaloric supplementation of a standard diet with fatty acids of varying degree of saturation does not affect either insulin secretion or insulin sensitivity in healthy men, due to the compensatory metabolic capacity of healthy subjects.