Two-dimensional finite element analysis of a polymer gel drug delivery system
Two-dimensional finite element analysis of a polymer gel drug delivery system
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DOI：
10.1016/0928-4931(95)00103-4
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发表时间：
1995-09
期刊：
影响因子：
--
通讯作者：
D. Segalman;W. Witkowski
中科院分区：
文献类型：
--
作者：
D. Segalman;W. Witkowski
水凝胶作为药物递送机制正在被研究。凝胶可以浸渍药物，然后通过各种方式刺激释放药物，具有数值预测释放过程的动态行为的能力将有利于这种过程的设计和控制。本文用有限元法模拟了受侵蚀的水泥土的动力特性。凝胶以塌陷状态浸渍。然后，它受到较高的pH环境，导致它膨胀。当它已经溶胀到特定程度时，凝胶侵蚀，从而释放药物试剂。目前正在研究这种凝胶在结肠给药方案中的应用。
Hydrogels are being investigated as drug delivery mechanisms. Gels can be impregnated with a drug and then stimulated through various means to release it. Having the capability to predict the dynamic behaviour of the release process numerically would benefit the design and control of such a process. In this paper, a finite element analysis is used to simulate the dynamic behaviour of an eroding polyelectrolyte gel. The gel is impregnated in a collapsed state. It is then subjected to a higher pH environment, causing it to swell. When it has swollen to a specified extent, the gel erodes, thereby releasing the drug agent. Such gels are currently being investigated in drug delivery schemes to the colon.