Filamentous influenza viruses.

Filamentous influenza viruses.
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DOI:
10.1099/jgv.0.000535
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发表时间:
2016-08
期刊:
The Journal of general virology
影响因子:
--
通讯作者:
Hutchinson EC
Hutchinson EC
中科院分区:
其他
文献类型:
--
作者:
Dadonaite B;Vijayakrishnan S;Fodor E;Bhella D;Hutchinson EC

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流感病毒的临床分离株产生多形病毒颗粒,包括极长的丝状病毒体。相比之下,适应实验室生长的流感病毒株通常只产生球形病毒体。因此,在大多数流感病毒的研究中,丝状表型一直被忽视。最近在成像和改进的动物模型方面的进展突出了丝状病毒体的独特结构和功能相关性。在这篇综述中,我们总结了目前已知的这些显着细长的病毒颗粒,并讨论了它们在临床感染中可能的作用。
Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarise what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
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