Neuronal activity in globus pallidus interna can be synchronized to local field potential activity over 3-12 Hz in patients with dystonia
Neuronal activity in globus pallidus interna can be synchronized to local field potential activity over 3-12 Hz in patients with dystonia
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DOI：
10.1016/j.expneurol.2006.07.011
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发表时间：
2006-12-01
影响因子：
5.3
通讯作者：
Brown, Peter
中科院分区：
文献类型：
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作者：
Chen, Chiung Chu;Kuehn, Andrea A.;Brown, Peter
肌张力障碍患者的局部场电位(LFP)的Pallidal记录显示出在3-12赫兹范围内的半振荡活动。尽管这种活动被认为与肌张力障碍有关，但目前尚不清楚这些LFP振荡在多大程度上发生在苍白球内侧(GPI)，并与局部神经元放电同步。因此，我们在功能性神经外科手术中记录了6例原发性肌张力障碍清醒患者九侧苍白球内植入微电极的LFP和神经元活动。归一化3~12 Hz以上的平均LFP功率GPI高于苍白球外球。计算了棘波触发的平均值，其中11个在3-12赫兹频段有显著特征，表明局部神经元的放电锁定在LFP的3-12赫兹振荡。除了两个以外，所有这些STA都在GPI中。我们的结论是，在肌张力障碍患者的手术靶点GPI中，3-12赫兹的苍白球振荡最大，并且它们可以与局部神经元的活动同步。这支持了LFP在3-12赫兹的活性与肌张力障碍之间的病理生理关系。(C)2006 Elsevier Inc.保留所有权利。
Pallidal recordings of local field potentials (LFPs) in patients with dystonia have demonstrated semi-oscillatory activity over 3-12 Hz. Although this activity has been hypothesized to contribute to dystonia, it is unclear to what extent these LFP oscillations arise in the globus pallidus interna (GPi) and are synchronous with local neuronal discharge. We therefore recorded LFPs and neuronal activity from microelectrodes inserted into the pallidum on nine sides in six awake patients with primary dystonia during functional neurosurgery. Mean normalized LFP power over 3-12 Hz was higher in GPi than globus pallidus externa. Spike triggered averages were computed, and 11 exhibited significant features in the 3-12 Hz band, indicating that the discharges of local neurons were locked to 3-12 Hz oscillations in the LFP. All but two of these STAs were in GPi. We conclude that pallidal oscillations at 3-12 Hz are maximal in GPi, the surgical target, in patients with dystonia and that they can be synchronized to activity in local neurons. This lends support to a pathophysiological relationship between LFP activity at 3-12 Hz and dystonia. (C) 2006 Elsevier Inc. All rights reserved.