Epidermal growth factor stimulates putrescine transport and ornithine decarboxylase activity in cultivated human fibroblasts.
Epidermal growth factor stimulates putrescine transport and ornithine decarboxylase activity in cultivated human fibroblasts.
复制标题
表皮生长因子刺激培养的人成纤维细胞中的腐胺转运和鸟氨酸脱羧酶活性。
DOI：
10.1016/0014-4827(78)90454-8
复制
发表时间：
1978
影响因子：
3.7
通讯作者：
J. Mcguire
中科院分区：
文献类型：
--
作者：
A. Dipasquale;Douglas White;J. Mcguire
许多观察结果将细胞内多胺水平的增加与细胞增殖速率的增加联系起来[6，7，10，23，25]。EGF刺激培养的人皮肤成纤维细胞和KB细胞的增殖。EGF通过两种机制增加多胺的细胞内水平，刺激鸟氨酸脱羧酶和多胺转运。EGF对细胞增殖的刺激可能是多胺浓度增加的作用。多胺腐胺、亚精胺和精胺被主动转运到细胞中，并且似乎具有相同的转运机制。
Many observations link increased intracellular polyamine levels with increased rates of cell proliferation [6, 7, 10, 23, 25]. EGF stimulates the proliferation of cultivated human skin fibroblasts and KB cells. EGF increases intracellular levels of polyamine through two mechanisms, the stimulation of both ornithine decarboxylase and polyamine transport. It is possible that the stimulation of cell proliferation by EGF may be an effect of increased polyamine concentration. The polyamines putrescine, spermidine, and spermine are actively transported into the cell and appear to share the same transport mechanism.