Breast lesions: Correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis
Breast lesions: Correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis
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DOI：
10.1148/radiology.200.3.8756909
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发表时间：
1996-09-01
期刊：
影响因子：
19.7
通讯作者：
Ohno, S
中科院分区：
文献类型：
--
作者：
Buadu, LD;Murakami, J;Ohno, S
目的：比较乳腺病变的定性和定量磁共振（MR）乳腺病变的乳腺X线摄影特征，尤其是肿瘤血管生成。材料和方法：73例患者（72名女性，一名男性，30-78岁；平均年龄； 51.0.0岁，51.0.0岁，51.0.0几年）可疑的乳房病变进行了MR成像。在所有患者中，进行了非对比度中等增强的定位成像，然后进行gadolin增强动态快速损坏的梯度回声（SPGR）成像。在选定的患者中，获得了快速SPGR图像。 Pearson和Spearman相关测试用于确定增强参数与微血管测定之间关系的强度。分泌：时间强度曲线类型与微血管密度级别相关（Spearman Rank相关测试：R = .90，P <.001）。对比介质吸收的最陡峭斜率与微血管计数相关（Pearson相关测试； r = .83，p <.001）。浸润性癌的外围增强（n = 9）与高外围和低中心微血管密度相关，这与脱木质和/或坏死有关。内部分隔（n = 2）仅在纤维瘤中观察到。结论：微血管的密度和分布可能在确定对比度培养基摄取的初始速率和肿瘤增强的异质性方面起着重要作用。
PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) mammographic features of breast lesions with histopathologic findings, especially tumor angiogenesis.MATERIALS AND METHODS: Seventy-three patients (72 women, one man; aged 30-78 years; mean age, 51.0 years) with suspicious breast lesions underwent MR imaging. Noncontrast medium-enhanced localization imaging and then gadolinium-enhanced dynamic fast spoiled gradient-recalled-echo (SPGR) imaging were performed in all patients. In selected patients, subtraction fast SPGR images were obtained. The Pearson and Spearman correlation tests were used to determine the strength of the relationships between enhancement parameters and microvessel determinations.RESULTS: Time intensity curve type correlated with microvessel density grade (Spearman rank correlation test: r = .90, P < .001). The steepest slope of contrast medium uptake correlated with microvessel counts (Pearson correlation test; r = .83, P < .001). Peripheral enhancement in invasive carcinomas (n = 9) correlated with high peripheral and low central microvessel densities, which were associated with desmoplasia and/or necrosis. Internal septations (n = 2) were seen only in fibroadenomas.CONCLUSION: The density and distribution of microvessels may play major roles in the determination of the initial rate of contrast medium uptake and the heterogeneity of tumor enhancement.