Impact of Perfluoropentane Microdroplets Diameter and Concentration on Acoustic Droplet Vaporization Transition Efficiency and Oxygen Scavenging.
Impact of Perfluoropentane Microdroplets Diameter and Concentration on Acoustic Droplet Vaporization Transition Efficiency and Oxygen Scavenging.
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DOI：
10.3390/pharmaceutics14112392
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发表时间：
2022-11-05
期刊：
影响因子：
5.4
通讯作者：
Haworth, Kevin J.
中科院分区：
文献类型：
--
作者：
Benton, Rachel P.;Al Rifai, Nour;Stone, Kateryna;Clark, Abigail;Zhang, Bin;Haworth, Kevin J.
关键词：
声学液滴汽化是超声作用下液滴转变为气体微泡的相变过程。相变后，氧气从周围的流体扩散到微气泡中。采用体外模型研究了液滴直径、超声造影剂的存在、超声占空比和液滴浓度对含氧去离子水中氧清除能力的影响。通过微流控方法制备了标称直径为1、3、5、7、9和12µm的全氟戊烷液滴，并在5.1×10−5~6.3×10−3 m L/m L的浓度范围内进行了研究。液滴暴露于由EkoSonicTM导管(2.35 MHz，47W，占空比为1.70%，2.34%或3.79%)转换的超声波中。随着液滴浓度的增加，氧清除量和相变的全氟戊烷总体积增大。ADV转换效率随液滴浓度的增加而降低。占空比的增加导致1、3、5和7微米液滴的氧气清除能力在统计上显著增加，尽管增加的幅度小于液滴直径或浓度增加时的增幅。在所测试的超声条件下，液滴直径和浓度对ADV的量和随后发生的氧清除的影响最大，在治疗性超声中使用ADV介导的氧清除时应考虑这一点。
Acoustic droplet vaporization is the ultrasound-mediated phase change of liquid droplets into gas microbubbles. Following the phase change, oxygen diffuses from the surrounding fluid into the microbubble. An in vitro model was used to study the effects of droplet diameter, the presence of an ultrasound contrast agent, ultrasound duty cycle, and droplet concentration on the magnitude of oxygen scavenging in oxygenated deionized water. Perfluoropentane droplets were manufactured through a microfluidic approach at nominal diameters of 1, 3, 5, 7, 9, and 12 µm and studied at concentrations varying from 5.1 × 10−5 to 6.3 × 10−3 mL/mL. Droplets were exposed to an ultrasound transduced by an EkoSonicTM catheter (2.35 MHz, 47 W, and duty cycles of 1.70%, 2.34%, or 3.79%). Oxygen scavenging and the total volume of perfluoropentane that phase-transitioned increased with droplet concentration. The ADV transition efficiency decreased with increasing droplet concentration. The increasing duty cycle resulted in statistically significant increases in oxygen scavenging for 1, 3, 5, and 7 µm droplets, although the increase was smaller than when the droplet diameter or concentration were increased. Under the ultrasound conditions tested, droplet diameter and concentration had the greatest impact on the amount of ADV and subsequent oxygen scavenging occurred, which should be considered when using ADV-mediated oxygen scavenging in therapeutic ultrasounds.
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DOI：
10.1177/10742484211046674
发表时间：
2021-11
影响因子：
2.6
作者：
Fischesser DM;Bo B;Benton RP;Su H;Jahanpanah N;Haworth KJ
通讯作者：
Haworth KJ
影响因子：
4.9
作者：
Aydin, Omer;Vlaisavljevich, Eli;ElSayed, Mohamed E. H.
通讯作者：
ElSayed, Mohamed E. H.
影响因子：
--
作者：
FASCIOLO, JC;CHIODI, H
通讯作者：
CHIODI, H
影响因子：
12.4
作者：
Lea-Banks, Harriet;O'Reilly, Meaghan A.;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
影响因子：
2.9
作者：
Burgess MT;Porter TM
通讯作者：
Porter TM