Normalization of diastolic dysfunction in type 2 diabetics after exercise training
Normalization of diastolic dysfunction in type 2 diabetics after exercise training
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DOI：
10.1249/mss.0b013e318145b642
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发表时间：
2007-11-01
期刊：
影响因子：
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通讯作者：
Poirier, Paul
中科院分区：
文献类型：
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作者：
Brassard, Patrice;Legault, Sylvie;Poirier, Paul
目的：本研究旨在评价有氧运动训练对2型糖尿病患者左室舒张功能障碍（LVDD）和运动能力的影响。研究方法：23名久坐不动的2型糖尿病受试者参加了这项研究，他们患有控制良好的2型糖尿病，没有冠心病，有不同程度的LVDD。受试者接受口服降糖药和/或饮食治疗。11名受试者（EX）（年龄：58 +/- 5岁;平均值+/- SD）使用自行车测力计进行了为期3个月的有氧运动训练计划，而对照组（CONT）的12名受试者（57 +/- 6岁）保持了日常生活活动。在3个月的运动计划前后，使用超声心动图评估运动能力和LVDD。结果如下：基线时，两组的人体测量数据相似，除了体重指数（BMI），CONT组更高（31 +/- 3 vs 28 +/- 3 kg中心点m（-2）; P < 0.05）。两组之间的血糖控制（HbA（Ic）：6.4 +/- 1.2 vs 5.8 +/- 1.3%; P = 0.2）或最大摄氧量（26.7 +/- 5.9 vs 28.6 +/- 3.9 mL中心点kg（-1）中心点min（-1）; P = 0.4）无显著差异。11例EX受试者中有5例LVDD恢复正常（P < 0.0001），其中4例在运动训练前为I级LVDD。CONT组舒张功能无变化。运动训练后，EX组的最大摄氧量增加（28.6 +/- 3.9 vs 32.7 +/- 5.7 mL中心点kg（-1）中心点min（-1）; P < 0.05），而CONT组无变化（26.7 ± 5.9 vs 27.3 ± 6.2 mL中心点kg（-1）中心点min（-1）; P = 0.58）。在两组中，BMI没有显著变化。结论：沿着运动能力的提高，有氧运动训练有可能逆转控制良好、无并发症的2型糖尿病患者的LVDD。
Purpose: The purpose of this study was to evaluate the impact of aerobic exercise training on left ventricular diastolic dysfunction (LVDD) and exercise capacity in subjects with type 2 diabetes. Methods: Twenty-three sedentary subjects with well-controlled type 2 diabetes, free of coronary disease and having different degrees of LVDD, participated in the study. Subjects were treated with oral hypoglycemic agents and/or diet. Eleven subjects (EX) (age: 58 +/- 5 yr; mean +/- SD) underwent a 3-month aerobic exercise training program using a cycle ergometer, whereas a control group (CONT) of 12 subjects (57 +/- 6 yr) maintained their activities of daily living. Exercise capacity and LVDD, using echocardiography, were evaluated before and after the 3-month exercise program. Results: At baseline, anthropometric data were similar between the groups, except for body mass index (BMI), which was higher in CONT (31 +/- 3 vs 28 +/- 3 kg center dot m(-2); P < 0.05). There were no significant differences in glycemic control (HbA(Ic): 6.4 +/- 1.2 vs 5.8 +/- 1.3%; P = 0.2) or maximal oxygen uptake (26.7 +/- 5.9 vs 28.6 +/- 3.9 mL center dot kg(-1)center dot min(-1); P = 0.4) between groups. Normalization of LVDD was observed in 5 of 11 EX subjects, (P < 0.0001) of whom four had grade I LVDD before exercise training. No change in diastolic function was observed in the CONT group. After exercise training, maximal oxygen uptake increased in the EX group (28.6 +/- 3.9 vs 32.7 +/- 5.7 mL center dot kg(-1)center dot min(-1); P < 0.05), whereas there was no change in the CONT group (26.7 +/- 5.9 vs 27.3 +/- 6.2 mL center dot kg(-1)center dot min(-1); P = 0.58). In both groups, there was no significant change in BMI. Conclusions: Along with an improvement in exercise capacity, aerobic exercise training has the potential to reverse LVDD in patients with well-controlled, uncomplicated type 2 diabetes.