Niacin treatment increases plasma homocyst(e)ine levels.
Niacin treatment increases plasma homocyst(e)ine levels.
复制标题
烟酸治疗会增加血浆同型半胱氨酸水平。
DOI：
10.1016/s0002-8703(99)70073-6
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发表时间：
1999
影响因子：
4.8
通讯作者：
Hunninghake,D
中科院分区：
文献类型：
--
作者：
Garg,R;Malinow,M;Pettinger,M;Upson,B;Hunninghake,D
背景研究已报道高水平的血浆同型半胱氨酸是动脉闭塞性疾病的独立危险因素。降低动脉粥样硬化的胆固醇研究报告称，与安慰剂相比，服用Colestiol和烟酸的患者血浆同型半胱氨酸(E)水平升高。因此，这项研究的目的是检查烟酸治疗对血浆同型半胱氨酸水平的影响。方法动脉疾病多干预试验是一项多中心、随机、安慰剂对照试验，比较了烟酸和安慰剂对52名外周动脉疾病参与者同型囊泡(E)碱的影响。结果在筛选阶段，烟酸剂量从10 0 mg/d滴定到10 0 0 mg/d，平均血浆同型半胱氨酸水平从13.1±4.4μ/L增加到15.3±5.6μ/L(P<0.0 0 1)。在随机化18周后，烟酸组的平均血浆同型半胱氨酸水平比基线增加了55%，而安慰剂组下降了7%(P=0.0001)。在48周的随访结束时，这一差异在统计学上仍然显著。结论：烟酸显著增加血浆同型半胱氨酸水平，这可能会降低烟酸与脂蛋白修饰相关的预期益处。然而，补充叶酸可以降低血浆同型半胱氨酸水平。因此，需要进一步的研究来确定长期接受烟酸治疗的患者补充B族维生素是否有益。(《美国心脏杂志》1999；138：1082-7)
Background Studies have reported high levels of plasma homocyst(e)ine as an independent risk factor for arterial occlusive disease. The Cholesterol Lowering Atherosclerosis Study reported an increase in plasma homocyst(e)ine levels in patients receiving both colestipol and niacin compared with placebo. Thus the objective of this study was to examine the effect of niacin treatment on plasma homocyst(e)ine levels. Methods The Arterial Disease Multiple Intervention Trial, a multicenter randomized, placebo-controlled trial, examined the effect of niacin compared with placebo on homocyst(e)ine in a subset of 52 participants with peripheral arterial disease. Results During the screening phase, titration of niacin dose from 100 mg to 1000 mg daily resulted in a 17% increase in mean plasma homocyst(e)ine level from 13.1 ± 4.4 μmol/L to 15.3 ± 5.6 μmol/L (P < .0001). At 18 weeks after randomization, there was an absolute 55% increase from baseline in mean plasma homocyst(e)ine levels in the niacin group and a 7% decrease in the placebo group (P = .0001). This difference remained statistically significant at the end of follow-up at 48 weeks. Conclusions Niacin substantially increased plasma homocyst(e)ine levels, which could potentially reduce the expected benefits of niacin associated with lipoprotein modification. However, plasma homocyst(e)ine levels can be decreased by folic acid supplementation. Thus further studies are needed to determine whether B vitamin supplementation to patients undergoing long-term niacin treatment would be beneficial. (Am Heart J 1999;138:1082-7.)
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影响因子：
5.3
作者：
T. Hayek;B. Fuhrman;Y. Levy;M. Aviram;Brook Jg
通讯作者：
Brook Jg
高同型半胱氨酸血症：间歇性跛行的独立危险因素
影响因子：
11.1
作者：
J. Mölgaard;M. Malinow;C. Lassvik;A. Holm;B. Upson;A. Olsson
通讯作者：
A. Olsson
影响因子：
158.5
作者：
SELHUB, J;JACQUES, PF;ROSENBERG, IH
通讯作者：
ROSENBERG, IH
DOI：
10.1001/jama.1992.03490070059042
发表时间：
1992-08
期刊：
JAMA
影响因子：
--
作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
通讯作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
影响因子：
4.3
作者：
L. Taylor;R. Defrang;E. Harris;J. Porter
通讯作者：
L. Taylor;R. Defrang;E. Harris;J. Porter