SYNERGY BETWEEN THE HUNCHBACK AND BICOID MORPHOGENS IS REQUIRED FOR ANTERIOR PATTERNING IN DROSOPHILA
SYNERGY BETWEEN THE HUNCHBACK AND BICOID MORPHOGENS IS REQUIRED FOR ANTERIOR PATTERNING IN DROSOPHILA
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DOI：
10.1016/s0092-8674(94)90622-x
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发表时间：
1994-09-09
期刊：
影响因子：
64.5
通讯作者：
DESPLAN, C
中科院分区：
文献类型：
--
作者：
SIMPSONBROSE, M;TREISMAN, J;DESPLAN, C
果蝇胚胎的前部图案化由差距基因的局部表达所指定，其由母体形态原bicoid（bcd）的梯度所控制。另一个母体成分，驼背（hb），可以在胸部和腹部替代bcd。在这里，我们证明了bcd执行其所有功能都需要hb。去除母体和合子hb产生的胚胎极性被破坏，不能正确表达所有已知的bcd靶基因。血红蛋白和头间隙基因的正确表达需要血红蛋白和bcd的协同激活。我们认为，是bcd和hb的联合作用，而不是bcd单独作用，形成了形态发生梯度，使极性沿沿着胚轴分布，并使胚胎定型。bcd可能是一个新获得的果蝇基因，它正在逐渐取代其他物种中由母体hb执行的一些功能。
Anterior patterning of the Drosophila embryo is specified by the localized expression of the gap genes, which is controlled by the gradient of the maternal morphogen bicoid (bcd). Another maternal component, hunch back (hb), can substitute for bcd in the thorax and abdomen. Here we show that hb is required for bcd to execute all of its functions. Removal of both maternal and zygotic hb produces embryos with disrupted polarity that fail to express all known bcd target genes correctly. Proper expression of hb and the head gap genes requires synergistic activation by hb and bcd. We propose that it is the combined activity of bcd and hb, and not bcd alone, that forms the morphogenetic gradient that specifies polarity along the embryonic axis and patterns the embryo. bcd may be a newly acquired Drosophila gene, which is gradually replacing some of the functions performed by maternal hb in other species.