Ultralow Voltage, OTFT-Based Sensor for Label-Free DNA Detection
Ultralow Voltage, OTFT-Based Sensor for Label-Free DNA Detection
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DOI：
10.1002/adma.201202996
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发表时间：
2013-01-04
影响因子：
29.4
通讯作者：
Bonfiglio, A.
中科院分区：
文献类型：
--
作者：
Lai, S.;Demelas, M.;Bonfiglio, A.
介绍了一种用于DNA杂交检测的有机超低压场效应管。这种转导机制是基于寡聚核苷酸的电荷引起的场效应调制，因此可以进行无标记检测。该装置显示出亚纳米级的检测极限和前所未有的单核苷酸多态选择性。
An organic ultralow voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows a sub-nanometer detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.