LIVER CYSTS IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE
LIVER CYSTS IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE
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DOI：
10.1016/0002-9343(80)90266-1
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发表时间：
1980-01-01
影响因子：
5.9
通讯作者：
BRYANT, JI
中科院分区：
文献类型：
--
作者：
MILUTINOVIC, J;FIALKOW, PJ;BRYANT, JI
来自 62 个无关家庭的 158 名 10 岁以上患有常染色体显性遗传型多囊肾病 (PKD) 的患者中，有 46 名 (29%) 发现了肝囊肿。在任何有 PKD 风险但未检测到肾囊肿的患者中均未发现肝囊肿。肝囊肿的患病率随着年龄的增长和肾小球滤过率的下降而增加。常染色体显性遗传型 PKD 患者的多囊肝病似乎是一种良性疾病，很少（如果有的话）导致肝功能受损或门静脉高压。
Liver cysts were found in 46 (29%) of 158 patients over 10 yr of age with documented autosomal dominant-type polycystic kidney disease (PKD) from 62 unrelated families. Hepatic cysts were not found in any patient at risk for PKD in whom renal cysts were not detected. The prevalence of liver cysts increased with advancing age and with declining rate of glomerular filtration. Polycystic liver disease in patients with autosomal dominant-type PKD appears to be a benign condition, rarely, if ever, causing impaired liver function or portal hypertension.