Salidroside promotes healthy longevity by interfering with HSP90 activity
Salidroside promotes healthy longevity by interfering with HSP90 activity
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DOI：
10.1007/s11357-023-00921-3
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发表时间：
2023-09-15
期刊：
影响因子：
5.6
通讯作者：
Dai，Fangyin
中科院分区：
文献类型：
--
作者：
Zhang，Jianfei;Li，Zhiquan;Dai，Fangyin
衰老是影响人类健康和生活质量的一个危险因素。筛选和开发新的补充剂和药物来对抗衰老和延缓衰老相关疾病的发生具有重要意义。本文研究了红景天主要天然小分子红景天苷（salidroside， SA）对红景天寿命和健康的影响及其抗衰老、抗氧化的分子机制。我们的研究结果表明，SA能有效延长寿命，并具有抗衰老和抗氧化的特性。计算机辅助方法、无标记相互作用分析和体外实验表明，SA直接结合热休克蛋白90 （HSP90）。此外，SA显著抑制HSP90的atp酶活性，影响HSP90与其相互作用蛋白的相互作用以及下游基因的表达，从而调控寿命和氧化应激反应。我们的研究结果为SA在多物种中的药理特性及其作为抗衰老药物的潜力提供了新的见解。
Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule fromRhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.