Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.
Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.
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DOI:
10.1016/j.stem.2012.02.008
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发表时间:
2012-03-02
期刊:
影响因子:
23.9
通讯作者:
Wang, Xiao-Fan
中科院分区:
文献类型:
--
作者:
Chen, Ye-Guang;Li, Zhongwei;Wang, Xiao-Fan
Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and pro-differentiation by regulating ERK and GSK3β/β-catenin signaling.
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