Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest
Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest
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DOI：
10.7554/elife.04585
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发表时间：
2015-02-09
期刊：
影响因子：
7.7
通讯作者：
Rushworth, Matthew F. S.
中科院分区：
文献类型：
--
作者：
Johnen, Vanessa M.;Neubert, Franz-Xaver;Rushworth, Matthew F. S.
两个区域之间的大脑活动相关性（功能连接）已被证明与其潜在的结构连接有关。我们研究的可能性，功能连接也反映了短期的变化，突触的功效。我们证明，在腹侧运动前皮层（PMv）和初级运动皮层（M1）附近，成对的经颅磁刺激（TMS）具有短的8ms脉冲间间隔，引起同步的突触前和突触后活动，并以与Hebbian可塑性一致的模式加强两个区域之间的区域间连接，导致PMv和M1之间的功能连接增加，如功能性磁共振成像（fMRI）所测量的。此外，我们表明，加强这些节点之间的连接有影响更广泛的网络区域，如减少耦合在并行电机编程流。对照实验表明，相同的TMS脉冲在相同的频率引起的fMRI测量的功能连接的变化时，脉冲间的间隔太长的赫布样可塑性。
Correlations in brain activity between two areas (functional connectivity) have been shown to relate to their underlying structural connections. We examine the possibility that functional connectivity also reflects short-term changes in synaptic efficacy. We demonstrate that paired transcranial magnetic stimulation (TMS) near ventral premotor cortex (PMv) and primary motor cortex (M1) with a short 8ms inter-pulse interval evoking synchronous pre- and post-synaptic activity and which strengthens interregional connectivity between the two areas in a pattern consistent with Hebbian plasticity, leads to increased functional connectivity between PMv and M1 as measured with functional magnetic resonance imaging (fMRI). Moreover, we show that strengthening connectivity between these nodes has effects on a wider network of areas, such as decreasing coupling in a parallel motor programming stream. A control experiment revealed that identical TMS pulses at identical frequencies caused no change in fMRI-measured functional connectivity when the inter-pulse-interval was too long for Hebbian-like plasticity.