Extranodal Extension as an Independent Prognostic factor in Laryngeal Squamous Cell Carcinoma Patients.
Extranodal Extension as an Independent Prognostic factor in Laryngeal Squamous Cell Carcinoma Patients.
复制标题
结外延伸作为喉鳞状细胞癌患者的独立预后因素
DOI：
10.7150/jca.47700
复制
发表时间：
2020
影响因子：
3.9
通讯作者：
Hu G
中科院分区：
文献类型：
--
作者：
Wang Z;Zeng Q;Li Y;Lu T;Liu C;Hu G
淋巴结转移伴结外扩展(ENE)被认为是影响头颈癌患者生存的一个重要的不良预后因素。本研究的目的是确定ENE对喉鳞状细胞癌(LSCC)患者的预后意义。355例喉癌患者接受了手术切除和颈淋巴清扫术。颈淋巴结状态分为三组：病理阴性结节(PN-)、病理阳性结节无ENE(ENE-)和病理阳性结节伴ENE(ENE+)。355例喉鳞癌中85例(23.9%)病理结节阳性，22/355例(6.2%)检出ENE。ENE与饮酒(p=0.005)、T分期(p=0.000)、肿瘤部位(p=0.000)和分化程度(p=0.000)有关。ENE+组的淋巴结转移率几乎是ENE-组的两倍(p=0.005)。PN-组、ENE-组和ENE+组的5年总生存率分别为86.4±2.6%、75.9±6.3%和53.7±12.7%(P=0.000)。在调整混杂变量后，ENE+的死亡风险是PN-病例的五倍以上(p=0.000)，死亡风险是ENE-病例的两倍多(p=0.036)。与n2-3/ene-病例相比，n2-3/ene+病例的存活率最低(p=0.013)。与PN-或ENE-状态相比，ENE+与较差的预后相关。ENE是喉鳞状细胞癌的独立预后因素，可作为是否需要辅助治疗的指标。
The presence of Lymph node metastasis with extranodal extension (ENE) is considered to be an important adverse prognostic factor for survival in patients with head and neck cancer. The aim of this study was to determine the prognostic significance of ENE in patients with laryngeal squamous cell carcinoma (LSCC). Three hundred and fifty-five patients with LSCC who underwent surgical resection and neck dissection were included. The status of cervical lymph node was classified into three groups: pathological negative nodal (pN-), pathological positive nodal without ENE (ENE-), and pathological positive nodal with ENE (ENE+). A total of 85 of 355 (23.9%) LSCC were pathological nodal positive, and ENE was detected in 22/355 (6.2%) patients. ENE was associated with drinking (p=0.005), T stage (p=0.000), tumor location (p=0.000), and differentiation degree (p=0.000). The number of lymph node metastasis in ENE+ group was associated with almost twice compared to ENE- group (p=0.005). The 5-year overall survival rates for patients in the pN-, ENE-, and ENE+ groups were 86.4±2.6%, 75.9±6.3%, and 53.7±12.7%, respectively (p=0.000). After adjusting for confounding variables, ENE+ was associated with more than five times the hazard of death than pN- cases (p=0.000), and more than twice the hazard of death than ENE- cases (p=0.036). Compared to N2-3/ENE- cases, N2-3/ENE+ cases had the poorest survival rate (p=0.013). ENE+ was associated with worse outcomes compared to pN - or ENE- status. ENE is an independent prognostic factor in LSCC, and could be an indicator of the need for adjuvant treatment.
登录
查看更多内容
DOI：
10.1016/0360-3016(92)90646-y
发表时间：
1992-01-01
影响因子：
7
作者：
HUANG, DT;JOHNSON, CR;GRIMES, M
通讯作者：
GRIMES, M
影响因子：
4.8
作者：
Liao, Chun-Ta;Hsueh, Chuen;Yen, Tzu-Chen
通讯作者：
Yen, Tzu-Chen
影响因子：
2.4
作者：
Suh S;Pak K;Seok JW;Kim IJ
通讯作者：
Kim IJ
影响因子：
4.6
作者：
Kim, Chan Wook;Kim, Jihun;Kim, Jin Cheon
通讯作者：
Kim, Jin Cheon
影响因子：
2.6
作者：
Ozturkcan, Sedat;Katilmis, Hueseyin;Dundar, Riza
通讯作者：
Dundar, Riza