Aberrant appearance of lung surfactant protein A in sera of patients with idiopathic pulmonary fibrosis and its clinical significance.
Aberrant appearance of lung surfactant protein A in sera of patients with idiopathic pulmonary fibrosis and its clinical significance.
复制标题
特发性肺纤维化患者血清肺表面活性蛋白A的异常表现及其临床意义
DOI：
10.1159/000196393
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Abe
中科院分区：
文献类型：
--
作者：
Y. Honda;Y. Kuroki;N. Shijubo;T. Fujishima;H. Takahashi;K. Hosoda;T. Akino;S. Abe
肺表面活性物质蛋白A（SP-A）是肺表面活性物质中主要的磷脂相关糖蛋白，对肺具有特异性。本研究采用酶联免疫吸附法测定了不同肺部疾病患者血清中SP-A浓度。特发性肺纤维化（IPF）和肺泡蛋白沉积症（PAP）患者血清SP-A浓度显著高于其他肺部疾病和健康志愿者，而肺结核、慢性肺气肿、弥漫性泛细支气管炎和细菌性肺炎患者血清SP-A浓度显著高于健康志愿者。连续测定2例IPF患者的血清SP-A水平可反映IPF的疾病活动性。IPF患者血清SP-A浓度与血清乳酸脱氢酶浓度显著相关，而与血沉、动脉血氧饱和度、肺活量和一氧化碳弥散量无显著相关性。血清SP-A的测定有助于IPF和PAP的诊断，并可反映IPF的病情活动性。
Pulmonary surfactant protein A (SP-A) is known to be a major phospholipid-associated glycoprotein in pulmonary surfactant, which is specific to the lung. In this study, the SP-A concentrations in sera of patients with various lung diseases were determined using an enzyme-linked immunosorbent assay. Patients with idiopathic pulmonary fibrosis (IPF) and pulmonary alveolar proteinosis (PAP) exhibited prominently high concentrations of serum SP-A compared to those of other lung diseases and healthy volunteers, although there were significant increases in serum SP-A concentrations in patients with pulmonary tuberculosis, chronic pulmonary emphysema, diffuse panbronchiolitis and bacterial pneumonia compared to those of healthy volunteers. Successive measurement in 2 patients with IPF showed that serum SP-A levels reflect the disease activity of IPF. In patients with IPF, serum SP-A concentrations were significantly correlated with those of serum lactate dehydrogenase, whereas there were no significant correlations of serum SP-A concentrations with erythrocyte sedimentation rate, arterial oxygen saturation, vital capacity and carbon monoxide diffusing capacity. Determination of serum SP-A will contribute to diagnosing IPF and PAP, and may reflect the disease activity of IPF.