Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers
Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers
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DOI：
10.1385/bter:110:3:193
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发表时间：
2006-06-01
影响因子：
3.9
通讯作者：
Quig, D
中科院分区：
文献类型：
--
作者：
Adams, JB;Holloway, CE;Quig, D
本研究的目的是评估自闭症谱系障碍儿童及其母亲的头发样本中 39 种有毒金属和必需矿物质的水平，并与对照组进行比较。采用电感耦合等离子体质谱法分析了自闭症谱系障碍儿童 (n=51)、其母亲子集 (n=29)、神经正常儿童 (n=40) 及其母亲子集 (n=25) 的头发元素含量。所有参与者都是从亚利桑那州招募的。自闭症儿童的碘水平低 45% (p=0.005)。患有异食癖的自闭症儿童的铬水平降低了 38% (p=0.002)。肌张力较低的自闭症儿童的钾水平非常低（-66%，p=0.01），而锌水平却很高（31%，p=0.01）。患有自闭症的幼儿的母亲的锂含量特别低（低 56%，p=0.005），患有自闭症的幼儿（3-6 岁）的锂含量也很低（-30%，p=0.04）。低碘水平与之前甲状腺功能异常的报告一致，甲状腺功能异常可能影响言语和认知技能的发展。母亲体内锂含量低可能导致幼儿体内锂含量低，这可能会影响他们的神经和免疫发育。有必要对碘、锂和其他元素进行进一步研究。
The objective of this study was to assess the levels of 39 toxic metals and essential minerals in hair samples of children with autism spectrum disorders and their mothers compared to controls. Inductively coupled plasma-mass spectrometry was used to analyze the elemental content of the hair of children with autism spectrum disorders (n=51), a subset of their mothers (n=29), neurotypical children (n=40), and a subset of their mothers (n=25). All participants were recruited from Arizona. Iodine levels were 45% lower in the children with autism (p=0.005). Autistic children with pica had a 38% lower level of chromium (p=0.002). Autistic children with low muscle tone had very low levels of potassium (-66%, p=0.01) and high zinc (31%, p=0.01). The mothers Of Young children with autism had especially low levels of lithium (56% lower, p=0.005), and the young children (ages 3-6 yr) with autism also had low lithium (-30%, p=0.04). Low iodine levels are consistent with previous reports of abnormal thyroid function, which likely affected development of speech and cognitive skills. Low lithium in the mothers likely caused low levels of lithium in the young children, which could have affected their neurological and immunological development. Further investigations of iodine, lithium, and other elements are warranted.