An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research
An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research
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DOI：
10.1186/1471-2393-11-71
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发表时间：
2011-10-12
影响因子：
3.1
通讯作者：
Gravett, Michael
中科院分区：
文献类型：
--
作者：
Gracie, Sara;Pennell, Craig;Gravett, Michael
早产是新生儿死亡和围产期发病的主要原因。早产的病因是多因素的，目前尚不清楚。随着PTB遗传因素的证据增加，在其研究中探索基因组学、转录组学、蛋白质组学和代谢组学的必要性也在增加。这篇评论建议进行高通量系统生物学调查早产的研究指南，期望这将有助于通过财团在国际上共享样本和数据，产生所需的权力，研究早产使用集成的“组学”技术。要解决的问题包括：（1）集成的“组学”方法，（2）表型，（3）样本收集，（4）数据管理-集成数据库，（5）国际财团和（6）翻译的可行性。本手稿是2009年4月在瑞士日内瓦世界卫生组织召开的早产国际合作会议上“-组学”工作组发起的讨论的产物。
Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multifactorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.