FTIR spectroscopic investigation and modeling of solute/polymer interactions in the hydrated state.
FTIR spectroscopic investigation and modeling of solute/polymer interactions in the hydrated state.
复制标题
水合状态下溶质/聚合物相互作用的 FTIR 光谱研究和建模。
DOI：
10.1163/156856299x00081
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Peppa,NA
中科院分区：
文献类型：
--
作者：
amEnde,MT;Peppa,NA
用衰减全反射红外光谱研究了奥普洛尔在转运过程中可能存在的相互作用。盐酸、牛血清白蛋白、α-糜蛋白酶和纤维蛋白原通过聚丙烯酸及其无规共聚凝胶。由于聚合物载体与被测药物之间的静电和氢键相互作用，使用了羰基和羧酸盐离子峰位移来识别药物/凝胶的结合。这些发现被用来解释药物通过这些凝胶扩散的计算扩散系数的下降以及相关的药物传输障碍。建立了一个模型来分析这种传输过程作为药物与聚合物结合热的函数。
Attenuated total reflectance infrared spectroscopy was used to investigate possible interactions during transport of oxprenolol . HCl, bovine serum albumin, α-chymotrypsin, and fibrinogen through poly(acrylic acid) and its random copolymeric gels. Carbonyl and carboxylate ion peak shifts were used to identify drug/gel binding due to electrostatic and hydrogen bond interactions between the polymer carrier and the drugs tested. These findings were used to interpret the decrease in calculated diffusion coefficients of drugs diffusing through these gels and the associated hindering of drug transport. A model was developed to analyze this transport process as a function of the binding heat of the drug with the polymer.